cinchona(redirected from Cinchona alkaloids)
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chinchona(chĭngkō`nə), name for species of the genus Cinchona, evergreen trees of the maddermadder,
common name for the Rubiaceae, a family of chiefly tropical and subtropical trees, shrubs, and herbs, especially abundant in N South America. The family is important economically for several tropical crops, e.g., coffee, quinine, and ipecac, and for many ornamentals, e.g.
..... Click the link for more information. family native to the Andean highlands from Bolivia to Colombia and also to some mountainous regions of Panama and Costa Rica. The trees are now cultivated elsewhere for "Peruvian bark," the source of quininequinine
, white crystalline alkaloid with a bitter taste. Before the development of more effective synthetic drugs such as quinacrine, chloroquine, and primaquine, quinine was the specific agent in the treatment of malaria.
..... Click the link for more information. . Quinine is still the drug of last resort in the treatment of malariamalaria,
infectious parasitic disease that can be either acute or chronic and is frequently recurrent. Malaria is common in Africa, Central and South America, the Mediterranean countries, Asia, and many of the Pacific islands.
..... Click the link for more information. , but its commercial importance was greatly reduced after the development of synthetic analogs in the 1950s. Several species yield quinine and several other antimalarial alkaloids. The bark of the uprooted tree is beaten loose, peeled by hand, and dried quickly to prevent the loss of alkaloids. Final extraction is conducted in factories.
The trees were named in honor of the countess of Chinchón who, legend says, was cured of a fever in 1638 by a preparation of the bark. Supposedly, at her instigation the bark was collected for malaria sufferers and later exported to Spain. Native peoples, however, had long used it for medicinal purposes and this use was observed by Jesuit missionaries, who brought the bark to Europe. Cinchona is sometimes called Jesuits' bark because of the part the group played in its dispersal. So successful were the Dutch and English in transplanting cinchona to Java and India that until World War II these countries, especially Java, grew practically the entire commercial supply.
Cinchona is classified in the division MagnoliophytaMagnoliophyta
, division of the plant kingdom consisting of those organisms commonly called the flowering plants, or angiosperms. The angiosperms have leaves, stems, and roots, and vascular, or conducting, tissue (xylem and phloem).
..... Click the link for more information. , class division Magnoliopsida, order Rubiales, family Rubiaceae.
See M. L. Duran-Reynals, The Fever Bark Tree (1946); P. E. Thompson and L. M. Werbel, Antimalarial Agents (1972); F. Rocco, The Miraculous Fever-Tree (2003).
a genus of evergreen tree of the family Rubiaceae. The trees are 10–15 m tall (some up to 25 m). The leaves are opposite, leathery, and entire. The pentamerous, tubular flowers are in cymose umbels, gathered into panicles. The corolla is pink or yellowish white and has lobes that are pubescent on the limb. The fruit is a dehiscent, bilocular, many-seeded, elongate capsule.
There are about 40 species, distributed in South America between 10° N lat. and 19° S lat. The trees grow at elevations of 1,600–2,400 m above sea level in forests on the eastern slopes of the Andes (C. officinalis is found at elevations to 3,300 m above sea level). The bark and other parts of the cinchona tree contain quinine, cinchonine, and other alkaloids that have antimalarial, tonic, and antiseptic effects. Since the 17th century, the tree has been greatly exploited for the healing properties of its bark. Despite a ban on export, Europeans sent cinchona seeds and seedlings to Java and India, where plantations were established. As a result of selection, the alkaloid content in the bark was raised from 2–2.5 percent to 16 percent. Several species, including C. ledgeriana, C. officinalis, and C. succirubra, and numerous hybrid forms are cultivated. In the USSR the cinchona tree is cultivated as an annual crop on the Black Sea coast of the Caucasus; cuttings and ovaries are preserved for the winter in hothouses. Cinchona culture is being curtailed as a result of the synthetic manufacture of its alkaloids.
REFERENCESAtlas lekarstvennykh rastenii SSSR. Moscow, 1962.
Zhukovskii, P. M. Kul’turnye rasteniia i ikh sorodichi, 3rd ed. Leningrad, 1971.
Murav’eva, D. A., and A. F. Gammerman. Tropicheskie i subtropicheskie lekarslvennye rasteniia. Moscow, 1974.
S. S. MORSHCHIKHINA