cis-active

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cis-active

[‚sis ′ak·tiv]
(cell and molecular biology)
Describing a genetic element (such as a promoter or other regulatory locus) that promotes or suppresses two unrelated targets (such as genes) on the same chromosome as a result of their relative positions on the chromosome.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins.
Most of these processes are controlled by auxin response genes, which are regulated at transcriptional level by cis-acting DNA elements in their promoter regions, including the auxin response element (AuxRE, TGTCTC), core of auxin response region (AuxRR-core, GGTCCAT), and TGA-element (AACGAC).
Stress-related cis-acting elements such as MBS (MYB transcription factor binding site), HSE (heat shock element), ABRE (ABA-responsive element), LTRE (low-temperature responsive element), CE3 (coupling element 3), and Wbox (WRKY transcription factor binding site) have been demonstrated to play a key role in the response of plants to stresses [44-48].
The putative promoter of CbCOR15 contains cis-acting elements that have been shown to mediate expression of cold-responsive genes of Arabidopsis thaliana.
By constructing and analyzing 5' and internal deletion mutants of the yeast KAR2 promoter, I succeeded in identifying a cis-acting element responsible for transcriptional induction of the yeast KAR2 gene in response to ER stress as a 22 bp UPR element (UPRE) in 1992.
In order to identify cis-regulatory sequences that were responsible for upregulation of IL-6 expression by NE, we generated the full-length IL-6 promoter (24) construct (1184 bp upstream of the transcription start site), designated as pIL-6P-luc1184, and the following three deletion mutants of pIL-6P-luc1184 as follows: i) pIL-6P-luc710, containing four cis-acting elements; ii) pIL-6P-luc204, deficient in a known AP-1 consensus sequence; and iii) pIL-6P-luc107, deficient in both a known AP-1 and a known CREB consensus sequence (Figure 4A).
They emphasize trans-acting and cis-acting components required for gene regulation, experimental and computational methods, and insights from a wide range of model bacterial organisms into principles of transcriptional regulation on a genomic scale.
Transposable elements, the promoter regions of housekeeping genes, and cis-acting regulatory elements of imprinted genes are three key epigenetic susceptibility targets containing CpG sites that are normally methylated, unmethylated, and differentially methylated, respectively.
Paramyxovirus genes are separated by cis-acting elements in the genome.