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(2001) suggested that clomiphene citrate may be adduct forming compound, which is able to inhibit replication if the cell lack DNA polymerase, or it may produce framshift mutations after replications.
Clomiphene citrate available in 50 mg tablets, under the trade name of clomitab was used in this experiment.
Clomiphene citrate has been the principal drug used for induction of ovulation in women with polycystic ovarian syndrome (PCOS).
Observations made during the present study indicate clomiphene citrate induced embryotoxicity and teratogenicity in mice.
He observed that preovulatory administration of clomiphene citrate caused dose dependent decrease of implantations and also caused growth retardation of surviving fetuses.
In 1980, Schardein reported the association of CNS malformation and clomiphene citrate. Eye abnormalities observed during the present study ranges from open eyelids to microphthalmia and anophthalmia.