clathrin


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clathrin

[′klath·rən]
(cell and molecular biology)
A protein that forms a lattice-shaped coating, through the assembly of subunits called triskelions, on the cytosolic side of membrane regions called coated pits during the initial stages of receptor-mediated endocytosis. Invagination of the pit results in a clathrin-coated vesicle.
References in periodicals archive ?
Horse clathrin heavy chain 2 isoform 6 (XP_023502409.1), also called solute carrier family 25 member 1 (SLC25A1), showed the highest protein sequence similarity to human CiC (query cover, 99%; identity, 97%).
The protein clathrin is a triskelion that diffuses freely throughout the cytoplasm and attaches to the cell membrane.
This regulation might be mediated by clathrin (28).
In the second mutant, [[beta]arr2.sub.TR366], we eliminated the predominant binding site (involving residues 367-385) for clathrins, which are proteins of the endocytic machinery, thereby essentially eliminating clathrin binding (approximately 90% reduced) (18, 19).
showed that clathrin is involved in GH/GHR internalization from the cell membrane (Strous and Govers, 1999).
Franceschelli et al., "Drug affinity responsive target stability (DARTS) identifies laurifolioside as a new clathrin heavy chain modulator," Journal of Natural Products, vol.
Barois et al., "Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division," PLoS Pathogens, vol.
Theoleyre et al., "OPG/membranous-RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation," Bone, vol.
Benichou et al., "Nef interacts with the l subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules," Immunity, vol.
Light-driven shedding is mediated by arrestin and clathrin (Sacunas et al., 2002) and is considered similar to the activity-dependent clathrin-mediated endocytosis of other G-protein-coupled receptors.
SNP Top BLASTx hit Accession 35,850 Clathrin heavy chain [Penaeus monodon] AJM87267.1 66,553 PREDICTED: ubiquitin XP_013776634.1 carboxyl-terminal hydrolase 24-like [Limulus polyphemus] 55,801 Polycomb protein Sfmbt [Zootermopsis KDR24213.1 nevadensis] 65,339 Reverse transcriptase [Penaeus monodon] ABB73282.1 13,995 YER163Cp-like protein [Saccharomyces EDZ72506.1 cerevisiae AW RI 1631 ] 65,420 Dia4p [Saccharomyces cerevisiae EGA62109.1 FostersO] 67,287 Reverse transcriptase [Penaeus monodon] ABB73282.1 51,829 Reverse transcriptase [Penaeus monodon] ABB73282.1 73,974 Silencing protein (Saccharomyces AAY22828.1 cerevisiae] 52,104 Acyl-CoA dehydrogenase [Herhaspirillum EJM97637.1 sp.

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