involving upper lip and or palate presents a challenge for the treating cleft care team members to restore esthetics and function.
. In: Lin KY, Ogle RC, Jane JA, editors.
is a common birth defect that occurs very early in pregnancy.
is affected by gender, geographic location, nationality, nutritional and periconceptional consumption of folic acid.
The transforming growth factor alpha (TGFA) gene is a well-studied candidate gene for oral clefting
. TGFA is expressed during craniofacial development in the medial edge epithelium of the palatal shelves.
(2008) A qualitative description of receiving a diagnosis of clefting
in the prenatal or postnatal period.
Cleft lip (cheiloschisis) and cleft palate (palatoschisis), which can also occur together as cleft lip and palate, are variations of a type of clefting
congenital deformity caused by abnormal facial development during gestation.
Clinically, the presenting signs appear along a wide spectrum, ranging from a simple cleft of the soft tissue to an extreme defect associated with clefting
of the mandible and/or sternum and a possible loss of other midline structures, such as portions of the hyoid bone.