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C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.



C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
Patients who have a sensitivity to oral progestin will be less likely to experience that with Climara Pro.
Another potential advantage [of Climara Pro] was that the patch had no impact on weight gain, which many patients are concerned about," said Dr.
Climara Pro, containing estradiol/ levonorgestrel, is a thin, translucent patch.
There are two main types of bioidentical hormones: those that are FDA-approved and commercially available with a prescription, such as Estrace, Climara, Vivelle, EstroGel, Divigel, and Estrasorb, and those that are produced on an individual basis for women in compounding pharmacies.
The newsletter will be mailed to CLIMARA patients enrolled in P*R*I*M*E.
In addition to "Health News", P*R*I*M*E features a toll-free 24-hour information line, 1-800-ONE-WK-4-U, to answer specific questions about menopause, ERT and CLIMARA.