Abbreviations A[beta]: Amyloid-[beta] AdoCbl: Adenosylcobalamin BSO: Buthionine sulfoximine Cbl: Cobalamin
CNCbl: Cyanocobalamin EAAT3: Excitatory amino acid transporter 3 EGF: Epidermal growth factor GSCbl: Glutathionylcobalamin GSH: The reduced glutathione GSSG: The oxidized glutathione HCY: Homocysteine IGF-1: Insulin-like growth factor 1 MeCbl: Methylcobalamin MS: Methionine synthase NAC: N-Acetylcysteine NRG-1: Neuregulin 1 OHCbl: Hydroxocobalamin PI3K: Phosphatidylinositol 3-kinase PLM: Phospholipid methylation PV+: Parvalbumin-expressing SAM: S-Adenosylmethionine SAH: S-Adenosylhomocysteine S[O.
Characterization of the cobalamins
attached to transcobalamin I and transcobalamin II in human plasma.
Spectroscopic studies of nitric oxide (NO) interactions with cobalamins
: reaction of NO with superoxocobalamin(III) likely accounts for cobalamin
reversal of the biological effects of NO.
Direct assay for cobalamin
bound to transcobalamin (holo-trascobalamin) in serum.
ARS scientists are testing various food and supplement samples using CE-ICP-MS to measure the various cobalamins
Conversely, approximately 75% of plasma cobalamin
binds to TCI, (2) a nonspecific R-binder protein similar to gastric R-binder protein ("R" denotes rapid electrophoretic mobility, distinguishable from intrinsic factor).
The cobalt in hydroxocobalamin is in the 3+ state and cobalamin
is abbreviated [Cbl.
12] levels owing to the measurement of nonactive cobalamin
Ageing is associated with a mild decline of cognitive skills but a severe decline of complex cognitive function may be attributed to extrinsic factors, such as cobalamin
Based on analyses in cobalamin
-deficient patients before and after therapy, Morkbak and colleagues (1) confirm our finding that cobalamin
concentrations correlate with haptocorrin (HC; transcobalamin I) (2) but propose that HC concentrations are regulated by cobalamin
status rather than being genetically deter mined, which they mistake as my view.
5) 28 MMA, [micro]mol/L 240 (71-563) 38 Cobalamins
, pmol/L 188 (81-770) 46 Total TC, pmol/L 1002 (544-1584) 22 HoloTC, pmol/L 53 (24-180) 55 TC saturation, fraction 0.
HoIoTC calibrators (Axis-Shield) were prepared gravimetrically from a stock solution of recombinant holoTC saturated with cobalamins