colchicine

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colchicine

(kŏl`chəsēn'), alkaloid extracted from plants of the genus Colchicum and especially from the corms of the autumn crocus, Colchicum autumnale (see meadow saffronmeadow saffron
or autumn crocus,
perennial garden ornamental (Colchicum autumnale) of the family Liliaceae (lily family). Native to Europe and N Africa, it has escaped from gardens to meadows and fields in some parts of the United States.
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). The metabolic effect of colchicine is not known, but it is thought that it may decrease production of lactic acid and prevent accumulation of uric acid crystals in the body, making it useful in the treatment of gout. Colchicine and derivatives such as demecolcine inhibit mitosismitosis
, process of nuclear division in a living cell by which the carriers of hereditary information, or the chromosomes, are exactly replicated and the two copies distributed to identical daughter nuclei.
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, or cell division. As a mitotic poison, it inhibits rapidly proliferating cells and has been used in cancer therapy and as an immunosuppressive drugimmunosuppressive drug,
any of a variety of substances used to prevent production of antibodies. They are commonly used to prevent rejection by a recipient's body of an organ transplanted from a donor.
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. Colchicine has also been used to visualize chromosomes photomicrographically and to induce mutations experimentally.

colchicine

[′käl·chə‚sēn]
(organic chemistry)
C22H25O6N An alkaloid extracted from the stem of the autumn crocus; used experimentally to inhibit spindle formation and delay centromere division, and medicinally in the treatment of gout.
References in periodicals archive ?
This new partnership will help enhance patient access to an important gout medicine by supplying Prasco with Colchicine Tablets, USP, manufactured under the same rigorous standards and processes as Colcrys.
URL Pharma, which made over USD430m in Colcrys sales in 2011, is currently owned by hedge fund Elliott Associates LP, venture capital investor Momar Corporation and Richard H.
We are certainly pleased to partner with Takeda, an established leader in providing gout treatment options, to make an Authorized Generic of Colcrys widely available, said Jonathan Lapps, Prasco s senior vice president, business development.
Since switching to Colcrys she started having more sores in her mouth.
The FDA's approval of Colcrys and the plans to ban the marketing of the older products has been sharply criticized by some clinicians who treat patients with gout because Colcrys is significantly more expensive than the older, unapproved formulations.
Gout Therapeutics Market to 2017 - Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market provides in-depth analysis of the drivers and barriers that affect the global musculoskeletal therapeutics market.
Davis to imply that the results are related to "using the Colcrys formulation," as the Colcrys formulation is colchicine, USP.
We are pleased to have URL Pharma's Colcrys added to our product portfolio and look forward to further realizing our goal of helping patients by providing multiple treatment options to manage the symptoms of acute and chronic gout in the U.
In total, we conducted 17 clinical studies enrolling almost 1,000 subjects, including a 575-patient, randomized, pivotal phase Ill study that discovered that, using the Colcrys formulation, gout flares can be treated with our three-tablet regimen, maintaining flail efficacy while significantly reducing most adverse reactions.
A request for a preliminary injunction to stop unapproved colchicine from being sold was denied, with the court noting that the plaintiff was doing the very same thing until the day before Colcrys was approved, but the suit is pending.
Some pharmacies only have Colcrys available," he added.
Colcrys complements Takeda's position in the gout marketplace with Uloric (febuxostat), which is used to lower blood uric acid levels in adults with gout.