colchicine

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colchicine

(kŏl`chəsēn'), alkaloid extracted from plants of the genus Colchicum and especially from the corms of the autumn crocus, Colchicum autumnale (see meadow saffronmeadow saffron
or autumn crocus,
perennial garden ornamental (Colchicum autumnale) of the family Liliaceae (lily family). Native to Europe and N Africa, it has escaped from gardens to meadows and fields in some parts of the United States.
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). The metabolic effect of colchicine is not known, but it is thought that it may decrease production of lactic acid and prevent accumulation of uric acid crystals in the body, making it useful in the treatment of gout. Colchicine and derivatives such as demecolcine inhibit mitosismitosis
, process of nuclear division in a living cell by which the carriers of hereditary information, or the chromosomes, are exactly replicated and the two copies distributed to identical daughter nuclei.
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, or cell division. As a mitotic poison, it inhibits rapidly proliferating cells and has been used in cancer therapy and as an immunosuppressive drugimmunosuppressive drug,
any of a variety of substances used to prevent production of antibodies. They are commonly used to prevent rejection by a recipient's body of an organ transplanted from a donor.
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. Colchicine has also been used to visualize chromosomes photomicrographically and to induce mutations experimentally.

colchicine

[′käl·chə‚sēn]
(organic chemistry)
C22H25O6N An alkaloid extracted from the stem of the autumn crocus; used experimentally to inhibit spindle formation and delay centromere division, and medicinally in the treatment of gout.
References in periodicals archive ?
This new partnership will help enhance patient access to an important gout medicine by supplying Prasco with Colchicine Tablets, USP, manufactured under the same rigorous standards and processes as Colcrys.
Prices for the Mitigare authorized generic and the Colcrys authorized generic have not been publicly announced.
We are certainly pleased to partner with Takeda, an established leader in providing gout treatment options, to make an Authorized Generic of Colcrys widely available, said Jonathan Lapps, Prasco s senior vice president, business development.
The number of gout patients is increasing year on year, and currently there are only three approved drugs in the market - Colcrys (colchicine), TMX 67 (febuxostat) and Krystexxa (pegloticase).
For further information, patients should speak with their healthcare provider and see the complete Prescribing Information and Medication Guide for COLCRYS.
The FDA statement notes that the manufacturer of Colcrys has established a patient assistance program for patients who can't afford the brand-name drug and those on Medicare who don't want the cost of the drug to contribute to their out-of-pocket Medicare Part D expenses.
Colcrys sells for about $5 per pill, according to DestinationRx.
About Colcrys Colcrys (colchicine, USP) is a prescription medicine used in adults for the treatment of flares associated with gout when taken at the first sign of a flare, as well as prevention of flares.
As per the agreement with Caraco, TPUSA will retain ownership of Colcrys and is exclusively responsible for the marketing and promotion of Colcrys.
We are pleased to have URL Pharma's Colcrys added to our product portfolio and look forward to further realizing our goal of helping patients by providing multiple treatment options to manage the symptoms of acute and chronic gout in the U.
The gout therapeutics market had only generics until the launch of Colcrys (colchicine) and TMX 67 (febuxostat) in 2009 and 2010 respectively.