collagenase

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collagenase

[′kä·lə·jə‚nās]
(biochemistry)
Any proteinase that decomposes collagen and gelatin.
References in periodicals archive ?
Lanz-Mendoza et al., "Entamoeba histolytica: erythrophagocytosis, collagenolysis, and liver abscess production as virulencemarkers," Transactions of the Royal Society of TropicalMedicine andHygiene, vol.
Evidence for increased collagenolysis by interstitial collagenases-1 and-3 in vulnerable human atheromatous plaques.
Inhibition by Retinoic Acid of Type IV Collagenolysis and Invasion Though Reconstituted Basement Membrane by Metastatic Rat Mammary Adenocarcinoma Cells Cancer Research 49 (7): 1698-1706.
Variable diameter of collagen fibrils found in this region and their breakdown into a granular deposit are typical for collagenolysis, as, for example, in the human uterine cervix when giving birth (Junqueira et al., 1980).
Keratomalacia is commonly encountered in dogs where there is rapid breakdown of corneal epithelium leading to melting of stroma or collagenolysis. Ulcers most commonly occur as a result of trauma and infection which erodes the outer protective layer and possibly deeper layers of cornea.
Collagenase activity in the conditioned media from skin and pubocervical fascia biopsy explant cultures is higher in biopsies taken from women with SUI; that circulating collagenolytic activity is higher in women with SUI and that urinary levels of collagen degradation products are higher in women with SUI, all provide supportive evidence for increased collagenolysis in the aetiology of SUI.
In a study about the histopathological effects of boron on mice liver at a dose of 12 mg/l in drinking water, it was detected that this level caused a significant increase in the numbers of binucleated cells in the adult mice and impaired collagenolysis in the livers of both juvenile and adult mice (Bustos-Obregon et al.) However, contrary to this study, in another study it was proposed that boron can be beneficial in the treatment of hepatocellular carcinoma.
(13) A characteristic finding is the presence of extensive collagenolysis and elastolysis, resulting in "floating fat" separated from the surrounding reticular dermis and the pannicular septa.