competitive inhibition

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competitive inhibition

[kəm′ped·əd·iv ‚in·ə′bish·ən]
(biochemistry)
Enzyme inhibition in which the inhibitor competes with the natural substrate for the active site of the enzyme; may be overcome by increasing substrate concentration.
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In this study, it is clear from the in vitro inhibition kinetic studies in rat liver microsomes that MA can act as competitive inhibitor to rat CYP2C11 with a of 98.
Perchlorate is a competitive inhibitor of the sodium iodide symporter (NIS), the thyroid cell-surface protein responsible for transporting iodide from the plasma into the thyroid.
Dihydrotanshinone was not only a potent competitive inhibitor of human CYP1A2 and CYP2C9, but also a potent noncompetitive inhibitor of human CYP3A4.
Tricyclic antidepressants block the reuptake of serotonin and norepinephrine, are competitive inhibitors of [H.
Oseltamivir and zanamivir are competitive inhibitors for the neuraminidase enzyme for the influenza virus.
Current approaches to neutralising chemoresistance have centred on developing competitive inhibitors.

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