Research has shown that an overactive complement system
plays a critical role in multiple disease conditions including the therapeutic areas of nephrology, hematology, ophthalmology and neurology.
ReAlta is dedicated to addressing life-threatening medical needs through beneficial inhibition of the Complement System
and Inflammatory Mechanisms.
Moreover, studies have reported the involvement of both Toll-like receptors (TLRs) and complement system
(5) in the development of CH.
AAV is a rare and life-threatening autoimmune disease in which activation of the complement system
, and specifically generation of C5a, is believed to play a key role in the neutrophil-driven vessel inflammation that defines the disease.
The Complement System
is composed of 30 blood proteins that are numbered as complement proteins: C1 to C9 with some appended with additional letter designation, e.g.
OMS721 is Omeros' lead human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), the effector enzyme of the lectin pathway of the complement system
Omeros controls the worldwide rights to MASP-2 and all therapeutics targeting MASP-2, a novel pro-inflammatory protein target involved in activation of the complement system
, which is an important component of the immune system.
Whilst I am aware its use is indicated in atypical haemolytic uraemic syndrome, I understood it is a monoclonal antibody targeted against the C5 component of the complement system
, and its action on complement is the mechanism of action in this and other disorders, such as paroxysmal nocturnal haemoglobinuria (2).
The product is the company's lead human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2, the effector enzyme of the lectin pathway of the complement system
The complement system
is the major effector of the humoral arm of the immune system.
Amplification of the inflammatory response, phagocytosis, lysis of pathogenic agents, and recognition of altered self are a few of the biological processes in which the Complement system
is involved [17-20].