Functional role of connexins
and pannexins in the interaction between vascular and nervous system.
7-11 The role of mitochondrial ion channels such as Bcl-2 in apoptosis is well-documented and, it is also likely that additional ion channels formed by the connexin
43 (Cx43) protein may play a similar role in cardiac myocyte apoptosis.
26, 32 and 43 are expressed in synoviocytes, and Cx43 is the most highly expressed connexin
in normal human synovial membranes.
2+]/calmodulin-dependent protein kinases II Cx43: Connexin
43 CV: Conduction velocity DAD: Delayed afterdepolarization EAD: Early afterdepolarization ICD: Implantable cardioverter defibrillator NCX: [Na.
TEHRAN (FNA)- How does a protein called connexin
put the clamps on cancer?
Impaired trafficking of connexins
in androgen-independent human prostate cancer cell lines and its migration by a-catenin.
are encoded by members of a multigene family, are defined by their molecular weight, and share high homology.
form intercellular channels by combining in groups of six to form a structure called a connexon.
Pierre et Marie Curie, Paris; AP-HP Hopital Charles Foix, Centre de Recherche et Developpement, Ivry-sur-Seine, France) introduces types of gap junctions, their structural aspects, expression patterns of connexins
(transmembrane proteins), and gap junction-related diseases due to mutations in connexin
CX26, CX32, and CX43, that form gap junctions and provide long range cell signaling within epithelia, appear down-regulated as the expression profiles of three malignant odontogenic tumors with those of the three benign ameloblastomas.
The involvement of other connexins
in regulating GC function cannot be ruled out (46).
, hearing and deafness: clinical aspects of mutations in the connexin