thalidomide

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Related to Contergan: Softenon

thalidomide

(thəlĭd`əmĭd'), sleep-inducing drug found to produce skeletal defects in developing fetuses. The drug was marketed in Europe, especially in West Germany and Britain, from 1957 to 1961, and was thought to be so safe that it was sold without prescription. In 1961 an extremely high incidence of European babies born with malformed, shortened limbs was correlated with use of thalidomide by women in their first trimester of pregnancy. Before it was recalled from use the drug had caused the malformation of about 8,000 children throughout the world.

Thalidomide never entirely disappeared from use, however, and it was later found to benefit some leprosyleprosy
or Hansen's disease
, chronic, mildly infectious malady capable of producing, when untreated, various deformities and disfigurements. It is caused by the rod-shaped bacterium Mycobacterium leprae, first described by G.
..... Click the link for more information.
 patients. In 1998, after a complex safety monitoring system had been established to prevent further birth defects, thalidomide was approved for use in the United States for a complication of leprosy. The drug is also used to treat multiple myeloma, a cancer that affects the bone marrow.

thalidomide

[thə′lid·ə‚mīd]
(pharmacology)
C13H10N2O4 A drug used as a sedative and hypnotic; may produce teratogenic effects when administered during pregnancy.

thalidomide

supposedly harmless sedative resulted in disfigured babies. [Am. Hist.: Van Doren, 582–583]

thalidomide

a. a synthetic drug formerly used as a sedative and hypnotic but withdrawn from the market when found to cause abnormalities in developing fetuses. Formula: C13H10N2O4
b. (as modifier): a thalidomide baby
References in periodicals archive ?
Contergan injuries: "Gesetz ueber die Errichtung einer Stiftung 'Hilfswerk fuer behinderte Kinder'" (Law Regarding Establishing a Foundation 'Relief for Handicapped Children') (December 17, 1971)See Bundesgesetzblatt 1971 I at 2018-2022 (Between 1957 and 1961, about 2,500 children were born with severe defects as a result of pregnant mothers' consumption of the sleeping pill "Contergan" which contained Thalidomid.
See CHRISTIAN BEYER, GRENZEN DER ARZNEIMITTELHAFTUNG DARGESTELLT AM BEISPIEL DES CONTERGAN FALLES (1989).