Coumarin

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Related to Coumarins: Tannins, Flavonoids

coumarin

[′kü·mə·rən]
(organic chemistry)
C9H6O2 The anhydride of o-coumaric acid; a toxic, white, crystalline lactone found in many plants and made synthetically; used in making perfume and soap. Also known as 1,2-benzopyrone.

Coumarin

 

a lactone of o-coumarinic acid; colorless crystals with an odor of new-mown hay. Melting point, 70°C; boiling point, 291°C. It has the following structural formula:

Coumarin is readily soluble in alcohol and ether and poorly soluble in water. It occurs in glucoside form in many plant species, for example, in sweet clover and sweet grass. Coumarin is industrially prepared from salicylic aldehyde and acetic anhydride. It serves as an odor-enhancing substance in the tobacco and perfume industries.

References in periodicals archive ?
217[degrees] dihedral angle between the newly formed ether ring and the two original coumarin rings, respectively.
Being a privileged scaffold, coumarins are reported to have bioactivities such as anticoagulant [3], anti-HIV [4, 5], antioxidant [6, 7], antibacterial [8], antiinflammatory [9, 10], anticancer [11], and dyslipidemic [12] activities.
It seems that quantitatively some phenolic compounds increased and others, such as catechein, coumarin, and cinnamic, found absent by irradiation treatment.
Results: The method established in this assay was successfully applied to the pharmacokinetic study of the selected coumarins in rat plasma after oral administration of the extract of ADR, and the pharmacokinetic characteristics of sixteen coumarins were clearly elucidated.
Column fractions of solanum incanum were subjected to various qualitative phytochemical tests like carbohydrates, tannin, saponin, alkaloid, quinines, glycosides, terpenoids, phenols and coumarin as per standard procedure (13,14).
EPs[R] 7630 (Dr William Schwabe Pharmaceuticals, Germany) is an aqueous ethanolic extract (11% m/m *; drug extract ratio 1:8-10) with characteristic constituents including highly oxygenated coumarins, simple phenols and high molecular weight proanthocyanidins.
For example, some coumarins inhibit the activity of vitamin K-dependent [gamma]-carboxylase involved in the activation of coagulation factors [16].
The topics include the eco-benign synthesis of indole derivatives employing diverse heterogeneous catalysts, solid heterogeneous catalysts based on sulfuric acid and transition-metal salts, the heterogeneous copper-catalyzed synthesis of bioactive heterocycles, silica sulfuric acid, applying silica-based heterogeneous catalysts, organometallic compounds, ultrasound as an efficient tool for synthesizing bioactive heterocycles, the synthesis of bioactive coumarins, silver, and mesoporous materials from a novel silica source.
11] show that Chaptalia species produce a greater variety of coumarins.
The presence of phytochemical compounds like alkaloids, steroids, terpenoids, tannins, saponins, coumarins, flavonoids, and naphthoquinones was qualitatively evaluated.