cyclooxygenase

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Related to Cox-2: Cox-1

cyclooxygenase

[‚sī·klō′äks·ə·jə‚nās]
(biochemistry)
An enzyme that catalyzes the conversion of arachidonic acid into prostaglandins.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Cox-2 expression was found to be up-regulated by 1.5-fold after bleomycin administration at both 50 and 100 [micro]g/mL doses in MLE-12 cells (Figure 4A).
Correlation of COX-2 expression with the grade of the tumour.
In this article, we describe our study to evaluate expression of VEGF and COX-2 markers in laryngeal and hypopharyngeal SCC and to correlate these data with tumor size.
Wnt/[beta]-Catenin, COX-2, and VEGF Were Involved in MK801-Induced Protection of Retinal Neuron Cells from Damage in NMDA-Treated Rats.
In feline genome COX-2 is present at chromosome D4, having 633 amino acids and 10 exons.
Conclusion: It was concluded that warfarin alters the inflammatory function of cells by directly influencing the IL-6 and COX-2 levels
Five patients were treated with selective COX-2 inhibitor; four of them received firocoxib (Previcox[R]), orally, in a daily dose of 5mg[kg.sup.-1].
This research aimed to study the mutations in BRCA1 and COX-2 isolated from tumor samples as compared to normal samples, secondly to find out the gene expression of BRCA1 and COX-2 in the tissues of mammary tumor as compared to normal mammary tissues and thirdly to co-relate the type of mutations with mammary tumors as compared to normal samples.
Editor's Note: "We found 30-day mortality from stroke increased by around 20% if patients were taking a COX-2 inhibitor before admission," said study co-author Christian Christiansen, PhD, of Aarhus University Hospital.
A virtual screening of potential inhibitors against COX-2 was performed using Molegro Virtual Docker software (MDV; http://www.molegro.com), its algorithm called MolDock showed a higher docking accuracy of 87% compared to other docking products in the market (Thomsen and Christensen 2006).
As a matter of fact, herbs such as turmeric, ginger, green tea, holy basil, and oregano, which have been customarily used in pain treatment for centuries, work similarly to NSAIDs and COX-2 (coxib) inhibitors, but without their disagreeable side effects.