It is thought that the selective inhibition of COX-2 by coxibs
results in a relative reduction in endothelial PGI2 synthesis, leaving platelet production of Tx[A.
Management pattern for patients with osteoarthritis treated with traditional non-steroidal anti-inflammatory drugs in Spain prior to introduction of Coxibs
There was, however, a lot of adverse publicity about the coxibs
, he noted, and patients who had been happy on an nsNSAID might not have been happy with the switch.
, selective inhibitors of cyclooxygenase-2.
Low-dose aspirin was synergistic with antithrombotic agents and corticosteroids, while coxibs
were synergistic with low-dose aspirin and SSRIs.
Specifically in Colombia, where the availability of new COXIBs
in veterinary medicine is non-existent, as well as the variety of breeds and crossbreeds, makes the use of these specific COX2 inhibitors a new therapeutic alternative for canines with articular pain.
And, all of this with their "natural" ease of use, economics of scale, and relatively minimal, or negligible, side effects --in comparison with conventional coxibs
Cardiovascular outcomes in new users of coxibs
and nonsteroidal antiinflammatory drugs: high-risk subgroups and time course of risk.
The original meta-analysis was published in the Lancet in 2013 and found that coxibs
or diclofenac conferred increased risk for major vascular events, and ibuprofen showed increased risk for coronary events, relative to placebo.
Athletes, NSAID, coxibs
, and the gastrointestinal tract.
37] In addition, all NSAIDs, both non-selective agents and coxibs
, confer an increased risk of thrombotic events, and should be used with caution in patients with cardiovascular risk factors.
possuem acoes anti-inflamatorias, antipireticas e analgesicas semelhantes aos AINEs tradicionais, porem nao compartilham de suas acoes antiplaquetarias, representando um grande avanco farmacologico, devido a diminuicao dos efeitos colaterais e maior seguranca para o sistema gastrintestinal, porem ainda persistem os potenciais efeitos colaterais adversos na funcao renal, moderados sintomas gastrintestinais e provaveis consequencias cardiovasculares e na fertilidade (KUMMER; COELHO, 2002; KATZUNG, 2010).