(redirected from Crinone)
Also found in: Dictionary, Thesaurus, Medical.


progesterone (prōjĕsˈtərōnˌ), female sex hormone that induces secretory changes in the lining of the uterus essential for successful implantation of a fertilized egg. A steroid, progesterone is secreted chiefly by the corpus luteum, a group of cells formed in the ovary after the follicle ruptures during the release of the egg cell. If fertilization does not take place, the secretion of progesterone decreases and menstruation occurs. If fertilization does occur, progesterone is secreted during pregnancy by the placenta and acts to prevent spontaneous abortion; the hormone also prepares the mammary glands for milk production. Progesterone is also synthesized from cholesterol in the cortex of the adrenal gland where it is a precursor for the synthesis of other steroids including testosterone. Synthetic compounds with progesteronelike activity have been developed that, along with estrogen, are used in oral contraceptives.
The Columbia Electronic Encyclopedia™ Copyright © 2022, Columbia University Press. Licensed from Columbia University Press. All rights reserved.


A steroid hormone produced in the corpus luteum and placenta. The hormone has an important physiological role in the luteal phase of the menstrual cycle and in the maintenance of pregnancy. In addition, progesterone produced in the testis and adrenals has a key role as an intermediate in the biosynthesis of androgens, estrogens, and the corticoids (adrenal cortex steroids). See Androgen, Cholesterol, Estrogen, Menstruation, Steroid, Sterol

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



in humans and vertebrate animals, a female sex hormone. Chemically, progesterone is a steroid that is synthesized in the body from cholesterol. It is an intermediate in the biosynthesis of all steroid hormones and can form in any tissues that secrete these hormones. Its structural formula is

In humans and higher animals, progesterone is primarily synthesized in the corpus luteum of the ovaries; the luteinizing hormone of the pituitary gland regulates its production. In the blood, progesterone mainly occurs in complexes with proteins.

By interacting with estriadol, another female hormone, progesterone regulates the estrous cycle in mammals and the menstrual cycle in humans. In the preovulatory phase of the sex and reproductive cycles in women, the daily production of progesterone occurs principally in the adrenal cortex and measures 1 to 3 mg. In the postovulatory phase, as much as 20 to 30 mg of progesterone are produced, principally in the corpus luteum. Progesterone produces changes in the uterine mucosa, which prepare the uterus for the implantation of the fertilized egg. When fertilization does not occur, the corpus luteum atrophies and the secretion of progesterone decreases. During a normal pregnancy, the placenta participates in the required daily production of as much as 200 to 250 mg of progesterone. Progesterone suppresses the activity of the smooth musculature of the uterus and thus prevents spontaneous abortion of the fetus; it also inhibits the ovulation of new follicles. The concentration of progesterone in the uterus decreases at the end of pregnancy, which serves as one of the trigger mechanisms of childbirth.

In medicine, progesterone and its synthetic derivatives (generally called progestins, or gestagens) are used to treat various disturbances of pregnancy and the ovarian cycle; they are also used in combination with estrogens as contraceptives. Derivatives of progesterone that act as repellents have been discovered in some insects. Flowering plants have also been found to produce progesterone.

In 1934, A. Butenandt contributed to the discovery of the chemical structure of progesterone.


Savchenko, O. N. Gormony iaichnika i gonadotropnye gormony. Leningrad, 1967.
Heftmann, E. M. Biokhimiia steroidov. Moscow, 1972. (Translated from English.)


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


C21H30O2 A steroid hormone produced in the corpus luteum, placenta, testes, and adrenals; plays an important physiological role in the luteal phase of the menstrual cycle and in the maintenance of pregnancy; it is an intermediate in the biosynthesis of androgens, estrogens, and the corticoids.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.


a steroid hormone, secreted mainly by the corpus luteum in the ovary, that prepares and maintains the uterus for pregnancy. Formula: C21H30O2
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
Luteal support for IVF/ICSI cycles with crinone 8% (90 mg) twice daily results in higher pregnancy rates than with intramuscular progesterone.
Comparison of the efficacy of two vaginal progesterone formulations, Crinone 8% gel and Utrogestan capsules, used for luteal support in blastocyst stage embryo transfers.
We are committed to reaching a beneficial conclusion on the pending litigation with Serono and achieving appreciable market penetration of a re-validated Crinone product.
Intravaginal crinone gel eliminates all of these effects, while maintaining the endometrial protective effect of progesterones.
Several meta-analyses as well as a recent large prospective, randomized trial have compared the efficacy of Crinone and intramuscular progesterone (IMP for luteal phase support during in vitro fertilization (IVF) and reported similar pregnancy rates and IVF cycle outcomes.
- Boston, Massachusetts-based women's health therapeutics company Juniper Pharmaceuticals (NASDAQ: JNP) has extended its supply agreement for Crinone (progesterone gel) with an affiliate of Merck KGaA, Darmstadt, Germany, the company said.
(23) evaluated artificial cycles with a transdermal estradiol patch in combination with the vaginal progesterone Crinone 8%.
Columbia Laboratories has renewed its license and supply agreement with Merck Serono for Crinone (progesterone gel) for an additional five years.
A new clinical option for hormone replacement therapy in women with secondary amenorrhea: effects of cyclic administration of progesterone from the sustained-release vaginal gel Crinone (4% and 8%) on endometrial morphologic features and withdrawal bleeding.
Food and Drug Administration has approved Crinone, a vaginal gel formulation of natural estrogen for treatment of amenorrhea and for infertility procedures, and an intra-uterine device that delivers progesterone directly to the uterus is an effective form of birth control and is sometimes used to treat abnormal uterine bleeding.
Four hundred milligrams per day of micronized progesterone (Progestin capsules 200 mg, Kogak Farma, Istanbul, Turkey) and 90 mg progesterone gel (Crinone gel, Merck, Switzerland) were applied vaginally for luteal phase support.
Drug development company Columbia Laboratories Inc (NasdaqCM:CBRX) reported on Thursday the early termination of the current exclusive supply agreement for CRINONE (progesterone gel) with Actavis Inc.