Crohn's disease


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Related to Crohn's disease: ulcerative colitis, colitis

Crohn's disease:

see colitiscolitis,
inflammation of the colon, or large intestine. The term "colitis" may be used to refer to any of a number of disorders involving the colon. Symptoms include diarrhea (often with blood and mucus), abdominal pain, and fever.
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Crohn's disease

[′krōnz diz‚ēz]
(medicine)
Chronic inflammation of the colon and stomach of unknown etiology that involves the full thickness of the intestinal wall, often with bowel narrowing and obstruction of the lumen. It is usually accompanied by granulomas; and abdominal cramps, alteration of bowel function, and diminished food intake are common.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Researchers are beginning to glean how cannabis may relieve symptoms of Crohn's disease. (Photo via Shutterstock)
Medicines used to treat ulcerative colitis or Crohn's disease include: | aminosalicylates or mesalazines - which can be given in a variety of ways | immunosuppressants - such as steroids or azathioprine to reduce the activity of the immune system | biologics - specific antibodybased treatments given by injection that target a specific part of the immune system | antibiotics It's estimated one in five people with ulcerative colitis have severe symptoms that don't improve with medication.
As we continue to advance the science of gastroenterology, we are hopeful that mirikizumab helps us raise the standard and make remission possible for people living with immune-mediated diseases like Crohn's disease. Physicians want objective signs of improvement to be able to convey to patients that they are getting better, and data from this study suggest mirikizumab may address this need.
The findings stress the importance of cancer surveillance for young patients with Ulcerative colitis or Crohn's disease. Also, the increased risk of suicide found in the study highlights the need to assess patients' mental health.
Your doctor will try to find out what's causing your symptoms and may refer you for tests to check for Crohn's disease.
A 35-year-old female patient presented with colon-involved Crohn's disease for 10 years.
Additionally, the recommendation was based on results from TiGenix's Phase III ADMIRE-CD pivotal trial, which showed that Alofisel achieved statistically significant superiority versus the control group in the primary efficacy endpoint of combined remission at 24 weeks, as well as further follow-up data that indicated Alofisel maintained long-term remission of treatment refractory complex perianal fistulas in patients with Crohn's disease over 52 weeks.
The phenotype of Crohn's disease was defined as B1, nonstricturing and nonpenetrating (inflammation); B2, stricturing; and B3, penetrating in the Montreal classification [13].
Medicines used to treat ulcerative colitis or Crohn's disease include: immunosuppressants to reduce the activity of the immune system and biologics - specific antibodybased treatments given by injection and antibiotics.
From 2003 to 2013, there was no significant change in the estimated number of hospitalizations for Crohn's disease as a first-listed diagnosis; however the age-adjusted hospitalization rate for Crohn's disease as any-listed diagnosis increased 35.1% from 44.2 per 100,000 (120,209 hospitalizations) in 2003 to 59.7 per 100,000 (196,480 hospitalizations) in 2013 (Table).
Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract, which is thought to affect up to 1.6 million people in Europe.
Historically, clinical indices (Crohn's disease activity index (CDAI), Harvey-Bradshaw index (HBI)) and systemic inflammatory markers (C-reactive protein (CRP)) have been used to assess disease activity in CD and have been found to correlate with levels of vitamin D [10, 11].