Croton Oil


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Related to Croton Oil: cascara sagrada

croton oil

[′krōt·ən ‚ȯil]
(materials)
A yellow-brown oil obtained from the seeds of the Croton tiglium; used as a purgative and as a substitute for castor oil.

Croton Oil

 

a thick brownish or yellow liquid obtained from the seeds of the purging croton (Croton tiglium). Croton oil acts as a strong cathartic and irritates the skin and mucous membranes. Even in small doses (over 20 drops), it can be fatal.

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paranense alkaloid fraction (0.01-0.73 mg/ear), solanine (0.001-0.37 mg/ear), or dexamethasone (0.1 mg/ear; used as a positive control) was dissolved in 20 [micro]L of acetone and applied topically before the croton oil treatment.
The ear edema was induced by a unique topical application of croton oil at a concentration of 1 mg/ear in the right ear of the mice and was manifested as an increase of ear thickness [4].
After 14 days of DMBA application, 1% croton oil was applied on skin after one hour of palmatine administration three times a week.
Ear edema induced by topical croton oil: Three groups of six mice were used.
Mice were anesthetized with ether and 20 [micro]l of an acetone solution containing 0.4 [micro]g croton oil and appropriate amounts of test samples were applied to the inner surface of the right ear of each mouse.
Groups of mice (n = 8-11) were treated subcutaneously with saline, KPFE (3,10, and 30 mg/kg), KPFV (0.3,1.0, and 3.0 mg/kg), or dexamethasone (2 mg/kg) 30 min before application of croton oil (2.5% in acetone, 20 [micro]L) on the inner surface of the right ear.
Inflammatory response was induced on the inner surface of the right ear (surface: about 1 [cm.sup.2]) by application of 80 [micro]g of Croton oil dissolved in an appropriate vehicle, as reported below.
Croton oil, indomethacin and ursolic and oleanolic acids were Sigma products (Sigma, Milan, Italy).
Hanks balanced salt solution (HBSS), croton oil, arachidonic acid, dextran, carrageenan, zymosan, plate-let-activating factor (PAF), indomethacin, phenylbutazone, methysergide, dexamethasone, phorbol-12-mirystate-13-acetate (PMA), N-formyl-methionyl-leucyl-phenylalanine (FMLP), sodium nitroprusside (SNP), W-13, H-7, genistein and propidium iodide were purchased from Sigma Chemical Co (USA).
In Group I, 93.75% of animals treated with DMBA and croton oil developed skin papillomas, and the average number of tumors per mouse (tumor burden) was 6.53.98.
Croton oil and indomethacin were Sigma products (St Louis, USA).