Cushing syndrome and Cushing disease
. JAMA 2011;306:2742.
Cabergoline therapy for Cushing disease
* The report provides a snapshot of the global therapeutic landscape of Pituitary ACTH Hypersecretion (Cushing Disease
The definitive diagnosis was Cushing Disease
in 10 subjects and ACTH-independent Cushing's syndrome due to an adrenal adenoma in 10 subjects.
Cushing described basophilic adenomas of the pituitary associated with Cushing disease
and described Cushing syndrome--the clinical effects of hyperadrenalism.
1), confirming a diagnosis of Cushing disease
. In Cushing disease
, at least a 50% rise in ACTH and a 20% rise in cortisol 30 min after CRH administration compared to baseline have been described as criteria providing 91% sensitivity and 95% specificity for pituitary Cushing (10).
Topics include the role pituitary tropic status has in tumor development, the estrous cycle as an instigator of anterior pituitary cell renewal, bone morphogenetic Protein-4 control of pituitary pathophysiology, and an animal model of prolactinoma, estrogen-treated animals to use in studies, the question of whether dopamine agonist treatment should be life-long, pituitary differentiation and regulation and the implications in hormone research, the regulation of growth hormone sensitivity by sex steroid, gene therapy in the neuroendocrine system, expression of somatostatin receptor subtypes and treatment outcomes, and new aspects in the diagnosis and treatment of Cushing Disease
. The editors have included a subject index.
Cushing syndrome is a metabolic disorder caused by chronically high levels of endogenous cortisol or by exogenous exposure to corticosteroids that impairs carbohydrate, protein, and lipid metabolism and includes all causes of hypercortisolism; on the other hand, the term Cushing disease
is reserved for cases of pituitary-dependent Cushing syndrome.
First-line treatment for Cushing disease
is surgical removal of the adrenocorticotrophin-secreting pituitary tumor.
Wilson, "Transsphenoidal microsurgery for Cushing disease
. A report of 216 cases," Annals of Internal Medicine, vol.