cyclin-dependent kinase

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cyclin-dependent kinase

[¦sī·klin di¦pen·dənt ′kī‚nās]
(cell and molecular biology)
A family of kinases that, once activated by cyclin, regulate the cell cycle by adding phosphate groups to a variety of protein substrates that control processes in the cycle. Abbreviated Cdk.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Seliciclib (CYC202 or r-roscovitine) is novel cell cycle drug belonging to the Cyclin Dependent Kinase (CDK) inhibitor class.
CYC202 (R-roscovitine) is a novel cell cycle drug belonging to the Cyclin Dependent Kinase (CDK) inhibitor class (US Patent 6,316,456).
CYC202, a Cyclin Dependent Kinase inhibitor in Phase II clinical trials for Non-Small Cell Lung cancer and in B cell hematological malignancies and CYC682 an orally available nucleoside analog in Phase Ib trials for cancer.
Most advanced is CYC202, a Cyclin Dependent Kinase (CDK) inhibitor, currently in Phase II trials for cancer.
It is claimed to be a selective cyclin dependent kinase inhibitor that will decrease the progress of cancer by inhibiting two proteins called cyclin dependent kinase 4 and 6 (CDK4/6).
Paracelsian's team of scientists discovered that there is a consistent relationship between cyclin dependent kinase concentrations and cell growth and proliferation.