The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
Frequent loss of expression of the cyclin-dependent kinase
inhibitor p27(Kip1) in estrogen-related Endometrial adenocarcinomas.
KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases
Overexpression of cyclin-dependent kinase
inhibitor 1 (WAF1) from the kinase inhibitor protein group and PAK-[gamma] (p21- activated kinase [gamma]), combined with overexpression of CDKN2D (p19-INK4D) and cell division protein kinase 3 (CDK3), denote a major derangement in the regulation of cell-cycle progression.
18) Cyclin D1 and cyclin-dependent kinases
are required for completion of the G1/S transition in normal mammalian cells.
Single Agent Activity of the Cyclin-Dependent Kinase
(CDK) Inhibitor Dinaciclib (SCH 727965) In Acute Myeloid and Lymphoid Leukemia Cells" (Abstract # 3981, Poster board #: III-760)
kip1]: a multifunctional cyclin-dependent kinase
inhibitor with prognostic significance in human cancers.
Genes essential for the yeast's survival would turn on only when the added DNA caused the yeast to produce a protein that bound to cyclin-dependent kinase
, also a protein.
RX-3117 is a small molecule, new chemical entity (NCE), nucleoside compound that inhibits DNA methyltransferase, a cyclin-dependent kinase
, and DNA synthesis.
Vladimir Bozhenko, Scientific Advisor of MetaMax says "Inhibition of cyclin-dependent kinase
4/6 is one of the most promising approaches in treatment of malignant diseases.
and licensed to RXi Pharmaceuticals encompassing small interfering RNA (siRNA) sequences targeting superoxide dismutase (SOD1), Amyloid beta (A4) precursor protein (APP), interleukin-1 receptor-associated kinase 4 (IRAK4), hepatocyte growth factor receptor (MET protooncogene) and cyclin-dependent kinase
(cdk) inhibitor p27 (also known as Kip1, CDKN1B).
G1's lead clinical candidate is a proprietary, potent and selective cyclin-dependent kinase
(CDK) 4/6 inhibitor that has been evaluated in a number of pre-clinical studies for the potential treatment of chemotherapy-induced myelosuppression.