Frequent loss of expression of the cyclin-dependent kinase
inhibitor p27(Kip1) in estrogen-related Endometrial adenocarcinomas.
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
Overexpression of cyclin-dependent kinase
inhibitor 1 (WAF1) from the kinase inhibitor protein group and PAK-[gamma] (p21- activated kinase [gamma]), combined with overexpression of CDKN2D (p19-INK4D) and cell division protein kinase 3 (CDK3), denote a major derangement in the regulation of cell-cycle progression.
KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases
Dinaciclib is a pro-apoptotic inhibitor of cyclin-dependent kinases
being evaluated by Merck for the potential treatment of cancer.
2] Genes: Cdkn2a, cyclin-dependent kinase
inhibitor 2A [Mus musculus gene]; Cdkn2b, cyclin-dependent kinase
inhibitor 2B [Mus musculus gene]; CDKN2A, cyclin-dependent kinase
inhibitor 2A (melanoma, p16, inhibits CDK4) [human gene]; CDKN2BB, cyclin-dependent kinase
inhibitor 2B (melanoma, p16, inhibits CDK4) [human gene].
kip1]: a multifunctional cyclin-dependent kinase
inhibitor with prognostic significance in human cancers.
They developed a screening test to determine what controlled the activity of a cyclin-dependent kinase
RX-3117 is a small molecule, new chemical entity (NCE), nucleoside compound that inhibits DNA methyltransferase, a cyclin-dependent kinase
, and DNA synthesis.
Indianapolis, Indiana-based global pharmaceuticals specialist Eli Lilly and Company's (NYSE: LLY) Phase 3 JUNIPER study evaluating Verzenio (abemaciclib), a cyclin-dependent kinase
4 and CDK6 inhibitor, as monotherapy in KRAS-mutated, advanced non-small lung cancer (NSCLC) did not meet its primary endpoint of overall survival (OS), the company said.
Kisqali (ribociclib) is a selective cyclin-dependent kinase
inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase
4 and 6 (CDK4/6).
18 SCIENCE, a team led by James Roberts of the Fred Hutchinson Cancer Research Center in Seattle reports that human cells about to copy their genes have high levels of two proteins -- cyclin E and cyclin-dependent kinase