cyclin

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cyclin

[′sī·klin]
(cell and molecular biology)
Any member of a family of proteins that regulate the cell cycle and whose cellular levels rise steadily until mitosis, then fall abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus toward mitosis.
References in periodicals archive ?
Fiaschi-Taesch, and the team discovered that combining elevated amounts of the regulatory molecules cdk4 or cdk6 with a variety of D-cyclin proteins, particularly cyclin D3, stimulates human beta cell replication in test tubes.
Overproduction of cyclins may stimulate abnormal cell growth and division, possibly leading to cancer.
Other bioactive compounds, such as cordycepin and zhankuic acid A, have been demonstrated to reduce the expression of MMP-9, cyclin E, cyclin D1 and to increase the expression of p21, p27.
1) Other mechanisms of endometrial carcinogenesis include mutations in p53 and PTEN tumor suppressor genes and overexpression of cyclin D1.
Further tests showed that the CIP1 protein fid not keep the kinase from attaching to cyclin but did make the pair ineffective in stimulating celL division, they report in the Nov.
The study was conducted to further investigate prior indications of the drug's ability to perturb cell cycle progression, focusing on the patterns of expression of cyclins and inhibitors of CDKs.
The cell cycle in cancer cells is frequently deregulated due to abnormal expression of cyclins and Cdks (Hartwell and Weinert 1989).
4] We previously showed that the cyclin D1 (CD1) gene, which is one of the cell-cycle regulator genes, was frequently amplified in esophageal carcinosarcoma.
Kerbel, "Clotrimazole and similar compounds target G1 cyclins, and the proteins which regulate translation initiation, which involve a far broader spectrum of cancers, including breast, colon, and lung carcinomas.
2]/M phases and affected cyclin B1, Bcl-2, and Ki67 expression.