cyclooxygenase

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Related to Cyclo-oxygenase: Cyclooxygenase 2 inhibitors

cyclooxygenase

[‚sī·klō′äks·ə·jə‚nās]
(biochemistry)
An enzyme that catalyzes the conversion of arachidonic acid into prostaglandins.
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Slides were then blocked again and treated with diluted primary antibody (rabbit anti-rat cyclo-oxygenase 2) in PBS.
placebo-treated individuals, suggest that cyclo-oxygenase inhibitors may
(20) According to Hawkey and Langman (33) although NSAIDs affect renal blood flow, their most consistent effect is in enhancing renal sodium reabsorption as a result of cyclo-oxygenase inhibition predisposing to increased blood pressure, peripheral oedema and hyperkalaemia.
This has the potential to increase nociceptive transduction and NSAIDs may not be as effective in the presence of exogenously supplied prostaglandin, because the cyclo-oxygenase enzyme inhibited is not responsible for the prostaglandin concentration in this setting.
Both NSAIDs and COX-2s work by inhibiting the enzyme cyclo-oxygenase (COX) which in turn stops the production of prostaglandins (PGE2 and PGF2[alpha]) and thromboxanes from membrane phospholipids.
Evidence suggests that there may be a synergistic relationship between AVP receptors and cyclo-oxygenase enzyme during antipyresis, and the presence of AVP may enhance the efficacy of nonsteroidal antipyretic drugs.
THEY home in on an enzyme, cyclo-oxygenase (COX), that appears only at the site of an injury.
This molecule is transformed into PGs via the cyclo-oxygenase enzyme pathway.
Searle discovered and developed Celebra, which blocks the activity of cyclo-oxygenase 2 (Cox-2))-an enzyme responsible for the pain and swelling of the joints associated with arthritis-more selectively than currently available products.
Aspirin inhibits platelet aggregation by reducing the activity of the enzyme cyclo-oxygenase that is necessary for the production of prostaglandins [41, 42].
The conversion of arachidonic acid (20:4) to cyclic endoperoxide ([PGG.sub.2]) is catalyzed by the enzyme cyclo-oxygenase. [PGG.sub.2] is converted to [PGE.sub.2] and [PGF.sub.2[Alpha]].
The investigators randomized 200 patients to 5 weeks of either weekly IA-HA or the nonselective cyclo-oxygenase inhibitor loxoprofen in three 60-mg tablets daily and evaluated patients percent change from baseline on the patient-reported Japanese Knee Osteoarthritis Measure (JKOM, primary endpoint) and their percent change from baseline in pain as rated on a 0- to 100-point visual analog scale (VAS, secondary endpoint).