cyclophilin

(redirected from Cyclophilins)
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cyclophilin

[‚sī·kə′fil·ən]
(biochemistry)
An abundant cytoplasmic protein that catalyzes cis-trans isomerizations; it has a high affinity for the immunosuppressive drug cyclosporin A.
References in periodicals archive ?
Cyclophilins assist in the folding and transport of other proteins synthesized within a cell.
A growing body of research has demonstrated the central role that cyclophilins play in catalyzing the folding of proteins, and their inhibition is an exciting avenue for therapeutic intervention and drug discovery," said Dr.
5 MSEK from the Swedish Foundation for Strategic Research (SFF) for an Industrial PhD to study the role of cyclophilins in liver cancer.
A cDNA clone for cyclophilin from Griffithsia japonica and phylogenetic analysis of cyclophilins.
It selectively targets and inhibits host cellular enzymes known as cyclophilins, which are commonly recruited by HBV and other viruses as part of their normal life cycle.
The four families of this class of enzymes are cyclophilins (Cyp), FK506-binding proteins (FKBPs), and pavilions which involved in protein folding (Lu et al.
Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion.
It targets a group of enzymes called cyclophilins, which play an important role in the development of acute inflammation.
Anderson LJ, Lin K, Compton T, Wiedmann B (2011) Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion.
Cyclophilins were found to be involved in different inflammatory conditions and the pathogenesis of several diseases.
Cyclophilins are ubiquitous proteins in human cells that are involved in protein folding.