Utilizing a mouse model of UTI, Hannan and coworkers have reported that early inhibition of cycloxygenase
activity decreases the incidence of recurrent UTI .
It is found to inhibit the production of nitric oxide, a pro-inflammatory mediator, and thus anti- inflammatory action might be mediated partly through this mechanism.19 TQ also inhibits the synthesis of prostaglandins (PGEs) and LTs by blocking the cycloxygenase
(COX) and lipoxygenase (LO) pathways of arachidonate metabolism, and is thus responsible for anti- inflammatory activity.20 TQ highly reduces the levels of IL- 1AY, IL-6, TNF-a and interferon gamma (IFN-) which are considered to be important pro-inflammatory mediators.21
Curcumin decrease cycloxygenase
2 expression and decreases serum leptin levels and thereby attenuates the risk of developing pre-malignant lesions in colon tissue (Kubota et al.
Different factors such as free radical and ROS scavenging, tissue necrosis factor (TNF)-a inhibition, cycloxygenase
pathway activation, and endothelial nitric oxide synthase activation were found to be responsible for cardiovascular protective effect.
Subsequently neutrophils, macrophages and polymorphonuclear leukocytes produce and release inflammatory mediators such as oxygen-flee radicals, proteolytic enzymes, and cycloxygenase
and lipoxygenase metabolites of arachidonic acid.
inhibition enhances the effects of surfactant therapy in endotoxininduced rat model of ARDS," Inflammation, vol.
Suppressive effect of natural sesquiterpenoids on inducible cycloxygenase
(COX-2) and nitric oxide synthase (iNOS) activity in mouse macrophase cells.
Natural products like esculetin, fraxetin, daphnetin and other related coumarin derivatives are recognized as inhibitors of the lipoxygenase and cycloxygenase
enzymic systems, and of neutrophil-dependent superoxide anion generation (Fylaktakidou et al.
The abdominal writhing induced by acetic acid involves the production and release of arachidonic acid metabolites via cycloxygenase
(COX) and prostaglandin biosynthesis (Elisabetsky et al.