Cystathionine


Also found in: Medical, Wikipedia.

Cystathionine

 

(also 2,7-diamino-4-thiasuberic acid), HOOCCH(NH2)CH2CH2SCH2CH(NH2)COOH, an amino acid containing a sulfide group. Cystathionine is an important intermediate in the biosynthesis and metabolism of amino acids containing sulfur. Of the four optically active and two racemic forms of the acid, only L-cystathionine and L-allo-cystathionine are biologically active. In mammals, L-cystathionine participates in the biosynthesis of cysteine from methionine and serine; in plants and bacteria, it participates in the biosynthesis of methionine from cysteine and homoserine.

References in periodicals archive ?
Homocystinuria is a rare inborn-error-inherited-metabolic disorder that results from a deficiency of an enzyme called cystathionine beta-synthase (CBS) enzyme.
Hydrogen sulfide ([H.sub.2]S) is predominantly synthesized from L-cysteine via cystathionine [gamma]-lyase in the heart and vasculature.
Cystathionine [gamma]-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failure.
The SNP may also increase/decrease the enzyme's activity in managing its cellular activity as happens with CBS (cystathionine beta-synthase).
The presentation describes the engineering of the cystathionine gamma-lyase enzyme scaffold into a novel molecule with a unique specificity for degrading both cystine and cysteine.
Wilcock et al .[3] demonstrated that DS could be triggered by abnormal proteins, including superoxide dismutase 1, collagen type VI, and cystathionine [sz]-synthase, which are encoded on chromosome 21.
Psychiatric manifestations of homocystinuria due to cystathionine beta-synthase deficiency: prevalence, natural history, and relationship to neurologic impairment and vitamin B6-responsiveness.
Some studies demonstrated the interaction between tryparedoxin and cystathionine [gamma]-lyase (CGL), (38) although the enzyme found in our experiment was cystathionine [beta]-synthase (CBS) (Tables 2 and 3, spots 5).
Upregulation of cysteine synthase and cystathionine [beta]-synthase contributes to Leishmania braziliensis survival under oxidative stress.
In the transsulfuration pathway, homocysteine produces cystathionine, the precursor for cysteine biosynthesis, catalyzed by vitamin B6-dependent cystathionine [beta]-synthase [5].
Tyagi, "Cystathionine beta synthase gene dose dependent vascular remodeling in murine model of hyperhomocysteinemia," International Journal of Physiology, Pathophysiology and Pharmacology, vol.