It is responsible for the regulation of catalytic activity and also brings about an association with cytokine receptor
. SH2 domain constitutes the JH 3 and part of JH 4 regions as shown in figure 2.4,6,7,9 Although the exact function of SH2 domain is not clear, some studies suggest that it acts as scaffolds.
It is an important anti-inflammatory marker of cytokine signaling gene and is encoded by the cytokine receptor
We questioned whether ASC populations are heterogenic in their cytokine secretion and cytokine receptor
We further analyzed the largest protein category, receptor, and found four subcategories: G-protein coupled receptor, cytokine receptor
, ligand-gated ion channel, and protein kinase receptor.
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor
In the acute phase of mental illness, elevations have been found in both interleukin-6 (IL-6) and the cytokine receptor
soluble IL-2 (SIL-2R); for MDD and schizophrenia, cytokine levels are acutely increased, tend to decrease with treatment, and eventually rise again, he said.
However, none of our patients were treated with anticytokine therapy, such as cytokine receptor
antibodies, cytokine signaling inhibitors, TNF-[alpha] blockers, or thalidomide.
Levels of cytokine receptor
activator of nuclear factor kappa B ligand in gingival crevicular fluid in untreated chronic periodontitis patients.
Besides IL-1[beta], IL-2, IL-4, IL-6, IL-17, IL-22, and TNF-[alpha], several other cytokines such as IL-10, interferon-[gamma] (IFN-[gamma]), transforming growth factor (TGF)-[beta], erythropoietin (EPO), cytokine receptors
such as the TNF-[alpha] receptors TNF-R p55 and TNF-Rp75, and cytokine receptor
antagonists such as the IL-1 receptor antagonist (IL-1ra) have been implicated in the pathophysiology of psychiatric and neurological disorders [2, 92, 93].
Timans et al., "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12R[beta]1 and a novel cytokine receptor
subunit, IL-23R," The Journal of Immunology, vol.
SOCS proteins can modulate cytokine receptor
signalling by multiple complementary mechanisms (Figure 4).
To this end we considered a group of cytokine receptor
genes which are orthologous in Mouse and Human, two species which diverged quite recently, some 65-85 MYA (million years ago) [32, 33].