cytotoxic T cell

(redirected from Cytotoxic T lymphocyte)
Also found in: Dictionary, Thesaurus, Medical, Wikipedia.

cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]

(immunology)

A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.

References in periodicals archive ?

"A low number of donor-specific cytotoxic T lymphocytes identifies patients in whom the immunosuppressive load can be safely reduced," the investigators concluded.

Measuring donor-specific cytotoxic T cells helps identify patients who can reduce immunosuppressive medication

In addition, IL-10 suppresses the cytotoxic activity of cytotoxic T lymphocytes by the reduction of MHC-I expression in target cells [62].

Description of [CD8.sup.+] Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia.

New Finding on Immune Response to HIV Tat May Contribute to Vaccine, Treatment

Ying, "Molecular and functional analysis of tyrosinase-related protein (TRP)-2 as a cytotoxic T lymphocyte target in patients with malignant glioma," Journal of Immunotherapy, vol.

A new hope in immunotherapy for malignant gliomas: adoptive T cell transfer therapy

Key words: Cytotoxic T lymphocyte antigen-4 (CTLA-4), A49G polymorphism, autoimmunity, idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, chronic lymphocytic leukemia

Cytotoxic T lymphocyte antigen-4 (CTLA-4) A49G polymorphism and autoimmune blood diseases / Sitotoksik T lenfosit antijen-4 (CTLA-4) A49G polimorfizmi ve otoimmun kan hastaliklari

Primary induction of human CD8+ cytotoxic T lymphocytes and interferon-gamma-producing T cells after smallpox vaccination.

Flow cytometry and T-cell response monitoring after smallpox vaccination

Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection.

Vaccines for mucosal immunity to combat emerging infectious diseases

According to the company, the patent is entitled "Composition and Method for Inducing and Enhancing a Telomerase Reverse Transcriptase-Reactive Cytotoxic T Lymphocyte Response", including claims for peptides that induce or enhance a cytotoxic T cell immune response against the human tumor antigen telomerase reverse transcriptase.

Adamis Pharmaceuticals Corporation awarded notice of allowance for US patent that covers its cancer immunology portfolio

Dorothee et al., "Cutaneous T cell lymphoma reactive CD4+ cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a Fas-independent pathway for specific tumor cell lysis," Journal of Investigative Dermatology, vol.

Tumor protective activity of CD4+ but not of CD8+ T cells in DNA-vaccinated mice challenged with bcr-abl-transformed cells

The patent includes claims covering composition of matter as well as methods of use and also encompass immunogens comprising a CD133 epitope and variants thereof as well as methods of using such immunogens in immunisation and to elicit cytotoxic T lymphocyte responses that are specific for tumour cells expressing HLA-A2.

ImmunoCellular Therapeutics Ltd wins key ICT-121 cancer vaccine patent

Absolute counts of CD4+ helper T lymphocytes and CD8+ cytotoxic T lymphocytes show marked depression proportionally (fig-1).

HYPER IMMUNOGLOBULIN E IGE SYNDROME (HIES) WITH PARTIAL T LYMPHOCYTES DEFICIENCY

Studies show that in Alopecia areata, failure of this immune privilege results in type 1 cellular immunity mediated by cytotoxic T lymphocytes which attack hair follicles and prevent them from entering the growing phase of the hair cycle.3 These cytotoxic T lymphocytes depend on the Interleukin-15 pathway which utilizes Janus Kinase (JAK) proteins for downstream signaling.