A low number of donor-specific
cytotoxic T lymphocytes identifies patients in whom the immunosuppressive load can be safely reduced," the investigators concluded.
Vaccinia virus-specific CD8+
cytotoxic T lymphocytes in humans.
Rotavirus-specific
cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection.
DSP-7888 is an investigational cancer peptide vaccine containing peptides that induce Wilms' tumor gene 1 -specific
cytotoxic T lymphocytes and helper T cells, which attack WT1-expressing cancerous cells found in various types of hematologic and solid cancers.
The analysis of the level of T lymphocytes' subpopulations showed that the group patients with serious severity is characterized by a decrease in
cytotoxic T lymphocytes content balanced by an increase in T-Helper lymphocytes (Figure 1).
When the immune cells known as cytotoxic lymphocytes (including
cytotoxic T lymphocytes and natural killer cells) are activated, "they produce a massive amount of perforin, yet the cells are fine," Voskoboinik said.
Subcutaneous panniculitic T-cell lymphoma is a tumor of
cytotoxic T lymphocytes.
Cytotoxic T lymphocytes also lyse HIV-infected cells and secrete HIV-suppressive factors.
To accomplish these duties, various types of T cells are used, including helper T cells (T-helper cells) and
cytotoxic T lymphocytes (CTLs).
These approaches include biologic therapy using interleukin (IL)-2, IL-12, interferon-alpha, monoclonal antibodies directed against B cell targets,
cytotoxic T lymphocytes directed against viral targets, immune-based therapy, stem cell reconstitution, angiogenesis inhibitors, therapeutic vaccines, and traditional cytotoxic chemotherapy regimens (often in combination with a biologic or immunologic approach).
OUR bodies naturally produce special killer cells, known as
cytotoxic T lymphocytes or CTLs, which target tumours and cells infected with viruses.
Non-personalized HIV immunotherapies are unable to raise
cytotoxic T lymphocytes against HIV antigens, fail to induce T cell memory, and, most importantly, do not provide antiviral protection against the patient's own particular virus," said Jean-Pierre Routy, M.
