A low number of donor-specific cytotoxic T lymphocytes
identifies patients in whom the immunosuppressive load can be safely reduced," the investigators concluded.
Vaccinia virus-specific CD8+ cytotoxic T lymphocytes
Rotavirus-specific cytotoxic T lymphocytes
appear at the intestinal mucosal surface after rotavirus infection.
DSP-7888 is an investigational cancer peptide vaccine containing peptides that induce Wilms' tumor gene 1 -specific cytotoxic T lymphocytes
and helper T cells, which attack WT1-expressing cancerous cells found in various types of hematologic and solid cancers.
The analysis of the level of T lymphocytes' subpopulations showed that the group patients with serious severity is characterized by a decrease in cytotoxic T lymphocytes
content balanced by an increase in T-Helper lymphocytes (Figure 1).
When the immune cells known as cytotoxic lymphocytes (including cytotoxic T lymphocytes
and natural killer cells) are activated, "they produce a massive amount of perforin, yet the cells are fine," Voskoboinik said.
Subcutaneous panniculitic T-cell lymphoma is a tumor of cytotoxic T lymphocytes
Cytotoxic T lymphocytes
also lyse HIV-infected cells and secrete HIV-suppressive factors.
To accomplish these duties, various types of T cells are used, including helper T cells (T-helper cells) and cytotoxic T lymphocytes
These approaches include biologic therapy using interleukin (IL)-2, IL-12, interferon-alpha, monoclonal antibodies directed against B cell targets, cytotoxic T lymphocytes
directed against viral targets, immune-based therapy, stem cell reconstitution, angiogenesis inhibitors, therapeutic vaccines, and traditional cytotoxic chemotherapy regimens (often in combination with a biologic or immunologic approach).
OUR bodies naturally produce special killer cells, known as cytotoxic T lymphocytes
or CTLs, which target tumours and cells infected with viruses.
Non-personalized HIV immunotherapies are unable to raise cytotoxic T lymphocytes
against HIV antigens, fail to induce T cell memory, and, most importantly, do not provide antiviral protection against the patient's own particular virus," said Jean-Pierre Routy, M.