"A low number of donor-specific cytotoxic T lymphocytes
identifies patients in whom the immunosuppressive load can be safely reduced," the investigators concluded.
In addition, IL-10 suppresses the cytotoxic activity of cytotoxic T lymphocytes
by the reduction of MHC-I expression in target cells .
Tat-specific cytotoxic T lymphocytes
select for SIV escape variants during resolution of primary viraemia.
Ying, "Molecular and functional analysis of tyrosinase-related protein (TRP)-2 as a cytotoxic T lymphocyte
target in patients with malignant glioma," Journal of Immunotherapy, vol.
Key words: Cytotoxic T lymphocyte
antigen-4 (CTLA-4), A49G polymorphism, autoimmunity, idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, chronic lymphocytic leukemia
Primary induction of human CD8+ cytotoxic T lymphocytes
and interferon-gamma-producing T cells after smallpox vaccination.
Rotavirus-specific cytotoxic T lymphocytes
appear at the intestinal mucosal surface after rotavirus infection.
According to the company, the patent is entitled "Composition and Method for Inducing and Enhancing a Telomerase Reverse Transcriptase-Reactive Cytotoxic T Lymphocyte
Response", including claims for peptides that induce or enhance a cytotoxic T cell immune response against the human tumor antigen telomerase reverse transcriptase.
Dorothee et al., "Cutaneous T cell lymphoma reactive CD4+ cytotoxic T lymphocyte
clones display a Th1 cytokine profile and use a Fas-independent pathway for specific tumor cell lysis," Journal of Investigative Dermatology, vol.
The patent includes claims covering composition of matter as well as methods of use and also encompass immunogens comprising a CD133 epitope and variants thereof as well as methods of using such immunogens in immunisation and to elicit cytotoxic T lymphocyte
responses that are specific for tumour cells expressing HLA-A2.
Absolute counts of CD4+ helper T lymphocytes and CD8+ cytotoxic T lymphocytes
show marked depression proportionally (fig-1).
Studies show that in Alopecia areata, failure of this immune privilege results in type 1 cellular immunity mediated by cytotoxic T lymphocytes
which attack hair follicles and prevent them from entering the growing phase of the hair cycle.3 These cytotoxic T lymphocytes
depend on the Interleukin-15 pathway which utilizes Janus Kinase (JAK) proteins for downstream signaling.