cytotoxic T cell

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cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
A low number of donor-specific cytotoxic T lymphocytes identifies patients in whom the immunosuppressive load can be safely reduced," the investigators concluded.
Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans.
Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection.
DSP-7888 is an investigational cancer peptide vaccine containing peptides that induce Wilms' tumor gene 1 -specific cytotoxic T lymphocytes and helper T cells, which attack WT1-expressing cancerous cells found in various types of hematologic and solid cancers.
The analysis of the level of T lymphocytes' subpopulations showed that the group patients with serious severity is characterized by a decrease in cytotoxic T lymphocytes content balanced by an increase in T-Helper lymphocytes (Figure 1).
When the immune cells known as cytotoxic lymphocytes (including cytotoxic T lymphocytes and natural killer cells) are activated, "they produce a massive amount of perforin, yet the cells are fine," Voskoboinik said.
Cytotoxic T lymphocytes also lyse HIV-infected cells and secrete HIV-suppressive factors.
To accomplish these duties, various types of T cells are used, including helper T cells (T-helper cells) and cytotoxic T lymphocytes (CTLs).
These approaches include biologic therapy using interleukin (IL)-2, IL-12, interferon-alpha, monoclonal antibodies directed against B cell targets, cytotoxic T lymphocytes directed against viral targets, immune-based therapy, stem cell reconstitution, angiogenesis inhibitors, therapeutic vaccines, and traditional cytotoxic chemotherapy regimens (often in combination with a biologic or immunologic approach).
OUR bodies naturally produce special killer cells, known as cytotoxic T lymphocytes or CTLs, which target tumours and cells infected with viruses.
Non-personalized HIV immunotherapies are unable to raise cytotoxic T lymphocytes against HIV antigens, fail to induce T cell memory, and, most importantly, do not provide antiviral protection against the patient's own particular virus," said Jean-Pierre Routy, M.
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