cytotoxic T cell

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cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
Acute rejection developed only in those with detectable levels of donor-specific cytotoxic T lymphocyte precursors before conversion.
Lillehei, "Treatment of recurrent glioma with intracavitary alloreactive cytotoxic T lymphocytes and interleukin-2," Cancer Immunology Immunotherapy, vol.
Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans.
Maeda et al., "Effect of asbestos exposure on differentiation of cytotoxic t lymphocytes in mixed lymphocyte reaction of human peripheral blood mononuclear cells," The American Journal of Respiratory Cell and Molecular Biology, vol.
* high levels of CD8 T cells (cytotoxic T lymphocytes) specific for proteins produced from the key viral genes gag, pol and env (J Virol, 69:9, p.
Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection.
Bleackley, "Cytotoxic T lymphocytes: all roads lead to death," Nature Reviews Immunology, vol.
According to the company, the Folate Binding Protein (FBP) is a well-validated therapeutic target nad is the source of immunogenic peptides like E39 that can stimulate cytotoxic T lymphocytes (CTL) to recognize and destroy preclinical FBP-expressing cancer cells.
The researchers believe that cytotoxic T lymphocytes play a role in the pathogenesis of emphysema.
Next, they isolated the cytotoxic T lymphocytes, killer white cells that destroy tumors.
Fujita, "Granule exocytosis, and not the Fas/Fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4+ as well as CD8+ cytotoxic T lymphocytes in humans," Blood, vol.
The Phase II combination study in newly diagnosed, metastatic RCC patients with unfavourable prognosis demonstrated decreases in T regulatory cells, along with a concurrent expansion of CD28+memory cytotoxic T lymphocytes (CTL).
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