Vaccinia virus-specific CD8+ cytotoxic T lymphocytes
Rotavirus-specific cytotoxic T lymphocytes
appear at the intestinal mucosal surface after rotavirus infection.
The authors demonstrated that the anti-tumor effect of talabostat appears to involve tumor-specific cytotoxic T lymphocytes
(CTL) and protective immunological memory.
The researchers believe that cytotoxic T lymphocytes
play a role in the pathogenesis of emphysema.
Next, they isolated the cytotoxic T lymphocytes
, killer white cells that destroy tumors.
The authors had previously found that telomere loss in cytotoxic T lymphocytes
(CTLs), the cells responsible for killing HIV-infected cells, was accelerated in AIDS patients, and contributed to the loss of anti-HIV activity that occurs during disease progression.
The Phase II combination study in newly diagnosed, metastatic RCC patients with unfavourable prognosis demonstrated decreases in T regulatory cells, along with a concurrent expansion of CD28+memory cytotoxic T lymphocytes
are studying the action of cytotoxic T lymphocytes
, cellular immune responders that attack foreign or infected cells.