Acute rejection developed only in those with detectable levels of donor-specific cytotoxic T lymphocyte
precursors before conversion.
Lillehei, "Treatment of recurrent glioma with intracavitary alloreactive cytotoxic T lymphocytes
and interleukin-2," Cancer Immunology Immunotherapy, vol.
Vaccinia virus-specific CD8+ cytotoxic T lymphocytes
Maeda et al., "Effect of asbestos exposure on differentiation of cytotoxic t lymphocytes
in mixed lymphocyte reaction of human peripheral blood mononuclear cells," The American Journal of Respiratory Cell and Molecular Biology, vol.
* high levels of CD8 T cells (cytotoxic T lymphocytes
) specific for proteins produced from the key viral genes gag, pol and env (J Virol, 69:9, p.
Rotavirus-specific cytotoxic T lymphocytes
appear at the intestinal mucosal surface after rotavirus infection.
Bleackley, "Cytotoxic T lymphocytes
: all roads lead to death," Nature Reviews Immunology, vol.
According to the company, the Folate Binding Protein (FBP) is a well-validated therapeutic target nad is the source of immunogenic peptides like E39 that can stimulate cytotoxic T lymphocytes
(CTL) to recognize and destroy preclinical FBP-expressing cancer cells.
The researchers believe that cytotoxic T lymphocytes
play a role in the pathogenesis of emphysema.
Next, they isolated the cytotoxic T lymphocytes
, killer white cells that destroy tumors.
Fujita, "Granule exocytosis, and not the Fas/Fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4+ as well as CD8+ cytotoxic T lymphocytes
in humans," Blood, vol.
The Phase II combination study in newly diagnosed, metastatic RCC patients with unfavourable prognosis demonstrated decreases in T regulatory cells, along with a concurrent expansion of CD28+memory cytotoxic T lymphocytes