cytotoxic T cell

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Related to Cytotoxic T-lymphocyte: Killer T cells, CD8+ cell

cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
* The report reviews Cytotoxic T-Lymphocyte Protein 4 (CTLA-4 or CD152) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Kasik, "There is an increase in expression of the cytotoxic T-lymphocyte antigen-2[alpha] gene during pregnancy," The American Journal of Obstetrics and Gynecology, vol.
MADRID -- For patients with resectable stage III melanoma, adjuvant therapy with the programmed death 1 (PD-1) immune checkpoint inhibitor nivolumab (Opdivo) was associated with significantly longer relapse-free survival compared with the cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibitor ipilimumab (Yervoy), results of a randomized phase 3 trial show.
The proportions of natural killer cells, CD8[sup]+, and interferon-a-secreting cells and tumor-specific cytotoxic T-lymphocyte activity were increased in the immunized group.
A monoclonal antibody administered intravenously, ipilimumab blocks cytotoxic T-lymphocyte antigen (CTLA-4), a molecule that the FDA said "may play a role in slowing down or turning off the body's immune system, affecting its ability to fight off cancerous cells [and] may work by allowing the body's immune system to recognize, target, and attack cells in melanoma tumors." It is being studied in other cancers as well.
The investigators determined that patients with heart failure had higher vaccine-induced interleukin-10 concentrations, suggesting a different cytotoxic T-lymphocyte phenotype for vaccine responses, and that heart failure patients mounted a less vigorous antibody immune response to the newest vaccine viral strain than did the healthy controls (J.
(14) Thus, ineffective cytotoxic T-lymphocyte response is the primary determinant of viral persistence in chronic hepatitis.
Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection.
Depletion of intracellular GSH by buthionine sulfoximine decreases the proportion of CD[8.sup.+] cells, inhibits the generation of large blastlike CD[8.sup.+] cells, and decreases cytotoxic T-lymphocyte activity (11).
We used PubMed and the China Knowledge Resource Integrated database up to June 2016, and related literatures about the relationships between the polymorphisms of CTLA4 and risks of PBC were researched on computer with retrieval words ("primary biliary cholangitis, PBC, cytotoxic T-lymphocyte antigen 4, Polymorphism, SNP, genetic variants").
According to the company, AGEN1884 is an immune checkpoint modulator (CPM) antibody that binds to cytotoxic T-lymphocyte antigen-4 (CTLA-4).
Antigen-specific cytotoxic T-lymphocyte (CTL) responses were observed against all four antigens (E6 and E7 proteins for HPV types 16 and 18).