* The report reviews Cytotoxic T-Lymphocyte
Protein 4 (CTLA-4 or CD152) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Kasik, "There is an increase in expression of the cytotoxic T-lymphocyte
antigen-2[alpha] gene during pregnancy," The American Journal of Obstetrics and Gynecology, vol.
MADRID -- For patients with resectable stage III melanoma, adjuvant therapy with the programmed death 1 (PD-1) immune checkpoint inhibitor nivolumab (Opdivo) was associated with significantly longer relapse-free survival compared with the cytotoxic T-lymphocyte
antigen 4 (CTLA-4) inhibitor ipilimumab (Yervoy), results of a randomized phase 3 trial show.
The proportions of natural killer cells, CD8[sup]+, and interferon-a-secreting cells and tumor-specific cytotoxic T-lymphocyte
activity were increased in the immunized group.
A monoclonal antibody administered intravenously, ipilimumab blocks cytotoxic T-lymphocyte
antigen (CTLA-4), a molecule that the FDA said "may play a role in slowing down or turning off the body's immune system, affecting its ability to fight off cancerous cells [and] may work by allowing the body's immune system to recognize, target, and attack cells in melanoma tumors." It is being studied in other cancers as well.
The investigators determined that patients with heart failure had higher vaccine-induced interleukin-10 concentrations, suggesting a different cytotoxic T-lymphocyte
phenotype for vaccine responses, and that heart failure patients mounted a less vigorous antibody immune response to the newest vaccine viral strain than did the healthy controls (J.
(14) Thus, ineffective cytotoxic T-lymphocyte
response is the primary determinant of viral persistence in chronic hepatitis.
Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte
response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection.
Depletion of intracellular GSH by buthionine sulfoximine decreases the proportion of CD[8.sup.+] cells, inhibits the generation of large blastlike CD[8.sup.+] cells, and decreases cytotoxic T-lymphocyte
We used PubMed and the China Knowledge Resource Integrated database up to June 2016, and related literatures about the relationships between the polymorphisms of CTLA4 and risks of PBC were researched on computer with retrieval words ("primary biliary cholangitis, PBC, cytotoxic T-lymphocyte
antigen 4, Polymorphism, SNP, genetic variants").
According to the company, AGEN1884 is an immune checkpoint modulator (CPM) antibody that binds to cytotoxic T-lymphocyte
Antigen-specific cytotoxic T-lymphocyte
(CTL) responses were observed against all four antigens (E6 and E7 proteins for HPV types 16 and 18).