cytotoxic T cell

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cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
References in periodicals archive ?
Other successful interventions based on EBV viral load monitoring that have been described include the combined use of antivirals and immunosuppression reduction [43] and the infusion of autologous EBV-specific cytotoxic T-lymphocytes [44].
Presentation of the disease such as primarily fever, hepatosplenomegaly, and cytopenia, which are the results of functional degradation in cytotoxic T-lymphocytes and natural killer cells, activation of macrophages and T-lymphocytes, over production of proinflammatory cytokines, and hemophagocytosis.
Immune regulatory index became normal as proportional of CD[4.sup.+]-cells and cytotoxic T-lymphocytes levels decreased.
The marked increase of T-suppressors/cytotoxic lymphocytes (CD8+) in the literature is described as a phenomenon that is realized in the period of pregnancy at the "mother-fetus" frontier for the elimination of cytotoxic T-lymphocytes directed against fetal antigens.
(12) Other cytotoxic T- lymphocyte mechanisms are regarded to play a role as well, such as Fas/Fas ligands or granulysis (a protein, discovered in granules of cytotoxic T-lymphocytes, which in combination with perforin reduces the vitality of a broad spectrum of pathogenic bacteria and through which T- cells directly contribute to the immunity against intracellular pathogens).
Survivin is recognized not only by antibodies but also by cytotoxic T-lymphocytes (7, 11).