Cytoxan


Also found in: Dictionary, Medical, Acronyms.
Related to Cytoxan: Taxol

Cytoxan

(sītŏk`sĭn), trade name for the drug cyclophosphamide, used to inhibit growth of tumors and rapidly proliferating cells. It is used in the treatment of leukemia, Hodgkin's disease, and lymphosarcoma and other solid tumors. A drug of great specificity, Cytoxan is activated in the body by the enzymes in certain types of tumors. Because it is also activated in such tissues as blood plasma and liver, it is a highly toxic substance. Nevertheless, it is a potent and useful chemotherapeutic agent.
The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved. www.cc.columbia.edu/cu/cup/
References in periodicals archive ?
"We are seeing what we believe to be dose-dependent marked increases in both absolute CD4 cell counts as well as the engraftment of CCR5 modified T cells with the increasing doses of Cytoxan," he said at the Conference on Retroviruses and Opportunistic Infections 2014.
"Any regimen that has an alkylating agent such as cyclophosphamide (Cytoxan), those patients are at high risk.
The immunosuppressive drugs include mitoxantrone (Novantrone), azathioprine (Imuran), methotrexate, cyclophosphamide (Cytoxan), or mycophenolate (CellCept).
These treatments include the chemotherapy agents mitoxantrone (Novantrone) and cyclophosphamide (Cytoxan) that suppress the immune system, and immune modulators rituximab (Rituxan) and fingolimod (Gilenya) that target immune cells thought to play a role in demyelination.
The women had early-stage breast cancer and received treatment including lumpectomy, radiation therapy and chemotherapy with cytoxan and adriamycin one to four years before the fracture occurred.
At approximately 46 weeks after presentation, cyclophosphamide (5 mg/kg PO q24h for 4 days, repeat in 21 days; Cytoxan, Bristol-Myers Squibb Company, Princeton, NJ, USA, compounded into a 5 mg/mL suspension by Carr Drugs) was added to the prednisone treatment; latex gloves were worn when handling the chemotherapeutic agent.
familiar as the weather--neutropenia, Adriamycin, Cytoxan,
Bye-bye Cytoxan, bye-bye Adriamcin, hello life again, I know that I'll survive.
The plan was to repeat his coagulation screen every week as we tapered his steroids, giving consideration to cytoxan or rituximab if he failed steroids.
Under some circumstances, chemotherapeutic drugs such as cyclophosphamide (Cytoxan) may be used to suppress the immune system and inflammation.
Cyclophosphamide (Cytoxan) is considerably more potent than methotrexate and is reserved for the most serious organ involvement.