"We are seeing what we believe to be dose-dependent marked increases in both absolute CD4 cell counts as well as the engraftment of CCR5 modified T cells with the increasing doses of Cytoxan
," he said at the Conference on Retroviruses and Opportunistic Infections 2014.
"Any regimen that has an alkylating agent such as cyclophosphamide (Cytoxan
), those patients are at high risk.
The immunosuppressive drugs include mitoxantrone (Novantrone), azathioprine (Imuran), methotrexate, cyclophosphamide (Cytoxan
), or mycophenolate (CellCept).
These treatments include the chemotherapy agents mitoxantrone (Novantrone) and cyclophosphamide (Cytoxan
) that suppress the immune system, and immune modulators rituximab (Rituxan) and fingolimod (Gilenya) that target immune cells thought to play a role in demyelination.
The women had early-stage breast cancer and received treatment including lumpectomy, radiation therapy and chemotherapy with cytoxan
and adriamycin one to four years before the fracture occurred.
At approximately 46 weeks after presentation, cyclophosphamide (5 mg/kg PO q24h for 4 days, repeat in 21 days; Cytoxan
, Bristol-Myers Squibb Company, Princeton, NJ, USA, compounded into a 5 mg/mL suspension by Carr Drugs) was added to the prednisone treatment; latex gloves were worn when handling the chemotherapeutic agent.
familiar as the weather--neutropenia, Adriamycin, Cytoxan
, bye-bye Adriamcin, hello life again, I know that I'll survive.
The plan was to repeat his coagulation screen every week as we tapered his steroids, giving consideration to cytoxan
or rituximab if he failed steroids.
Under some circumstances, chemotherapeutic drugs such as cyclophosphamide (Cytoxan
) may be used to suppress the immune system and inflammation.
) is considerably more potent than methotrexate and is reserved for the most serious organ involvement.