Glucuronic Acid

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glucuronic acid

[¦glü·kyə¦rän·ik ′as·əd]
(biochemistry)
C6H10O7 An acid resulting from oxidation of the CH2OH radical ofD-glucose to COOH; a component of many polysaccharides and certain vegetable gums. Also known as glycuronic acid.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Glucuronic Acid

 

one of the uronic acids, COH(CHOH)4COOH; it is formed in the body from glucose when the latter is oxidized by a primary alcohol group. It is optically active and dissolves readily in water. Melting point, 167°-172° C. D-glucuronic acid is widespread in the animal and vegetable worlds and is a component of acid mucopolysaccharides, some bacterial polysaccharides, triterpenoid saponins, hemicellulose, and gums. Free glucuronic acid is found in blood and urine in small quantities. Certain metabolic products, including some toxic products (phenol and cresol), as well as many medications, are discharged with the urine in the form of sister compounds of glucuronic acid (glucuronides). Conversions of glucuronic acid in all animals except the monkey and guinea pig, as well as in humans, lead to the biosynthesis of ascorbic acid. Body fluids and tissues of animals (especially the liver, kidneys, and spleen, and also malignant tumors) and bacterial and plant tissues contain the enzyme β-glucuronidase, which catalyzes the hydrolysis of β-glucuronides to free glucuronic acid and the corresponding aglycon.

G. A. SOLOV’EVA

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
It's an extremely large molecule composed of many repeating units of the disaccharide, D-N-acetylglucosamine, and D-glucuronic acid, linked together via alternating beta-1,4 and beta-1,3 glycosidic bonds.
It is a high-molecular-weight complex acid polysaccharide and is composed of L-arabinose, D-galactose, D-mannose, D-xylose and D-glucuronic acid. It contains approximately 3% protein.
D-Glucaric acid was measured by high-performance liquid chromatography with an ultraviolet detector after pretreatment of urine with boronic acid gel to remove interfering substances such as L-ascorbic acid and D-glucuronic acid (Pooh et al.
Chondroitin sulfate C, primarily found in fish and shark cartilage, but also in humans, is also made up of linear repeating units of D-galactosamine and D-glucuronic acid. Chondroitin sulfate C is sometimes called chondroitin 6-sulfate.
The second fraction was a pectic polysaccharide composed of 2,4-linked and 2-linked L-rhamnose, 6-linked D-galactose, a terminal non-reducing D-glucuronic acid and 4-linked D-galacturonic acid [52].