penicillamine

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penicillamine

[‚pen·ə′sil·ə‚mēn]
(pharmacology)
C5H11NO2S The most characteristic degradation product of penicillin-type antibiotics; used as a chelating agent, as a drug to reduce cystine excretion in cystinurea, and in the treatment of rheumatoid arthritis.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The present study was conducted to evaluate the effects of subchronic oral lead intoxication on blood indices of adult rats and efficacy of D-penicillamine in reducing these effects.
"The effects of d-penicillamine on the tissue distribution and excretion of lead." Toxicol Appl Pharmacol, 1973; 26:241-246.
In November 1983, Charlotte again returned to Mayo, her skin blistered from a reaction to the D-penicillamine and her itching more persistent than ever because she had weaned herself from the pheresis machine.
The treatment modalities for morphea include phototherapy, topical tacrolimus, calcipotriol in combination with betamethasone dipropionate, Imiquimod, methotrexate in combination with systemic steroids, cyclosporine, D-penicillamine, mycophenolate mofetil, photophoresis, etc.15 Our case was managed with topical tacrolimus 0.1% ointment and emollients and with oral sodium levothyroxine 25 g/day.
Streem called tiopronin (Thiola) the drug of choice because it is less likely than D-penicillamine to cause side effects.
Their joint studies have yielded important findings: Drugs such as hydroxychloroquine, d-penicillamine and auranofin have been shown to be no more effective than a placebo, whereas methotrexate has been found to be extremely effective in treating the disease.
He was started on an 8-week course of outpatient chelation with D-penicillamine (PCA) in November 1990.
Biosynthesis and maturation of skin collagen in scleroderma and effect of D-penicillamine. Lancet.
The diagnosis of Wilson's disease was made and the patient was started on d-penicillamine therapy and zinc.
Three clinical variants of EPS can be detected: idiopathic, with a genetic base without any well-known cause; reactive, related to systemic diseases such as Marfan syndrome, Ehlers-Danlos syndrome, Down syndrome, pseudoxanthoma elasticum, and other fibrous tissue diseases (1, 3); and drug-induced, caused by D-penicillamine (4).