cohesive end

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cohesive end

[kō′hē·siv ‚end]
(biochemistry)
References in periodicals archive ?
2003) Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutation at these sites on DNA end joining in a cell-free system.
Single-strand annealing, conservative homologous recombination, nonhomologous DNA end joining, and the cell cycle-dependent repair of DNA double-strand breaks induced by sparsely or densely ionizing radiation.
It then performs a chemical reaction on the damaged DNA end, reversing the damage and releasing it so that the broken DNA strand can be welded together with the rest of the double helix.
Actively dividing somatic cells do not effectively compensate the loss of telomeric sequences due to the DNA end replication problem (Counter et al.
Telomerase and DNA end replication: no longer a lagging strand problem?
DNA end processing is a major determinant of DSB repair outcome.
During BIR, one broken DNA end is paired with an identical DNA sequence on another chromosome and initiates an unusual type of replication, which proceeds as a migrating bubble and is associated with the accumulation of large amounts of single-strand DNA," she said.
Schellenberg explained that TOP2 normally conceals its cut DNA ends within the core of the TOP2 protein that encircles DNA.
Cleaved DNA ends were then re-united to each other either through non homologous recombination (NHR) or homologous recombination (HR)[13].
Nevertheless, erroneous or abortive topoisomerase activity can result in persistent DNA strand breaks with the enzyme covalently attached to 3 or 5 DNA ends by a phosphotyrosyl bond, an anomalous structure that can compromise cell survival and/or genome integrity with the consequent implications in tumourigenesis.
The majority of HR repair is mediated by Rad52 epistasis group that includes the Rad51, Rad52, Rad54, Rad55, Rad57, MRE11 and NBS1 function in the initial sensor of the broken DNA ends (Sonoda et al.