DNA

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Related to DNA gyrase: Topoisomerase, Quinolones

DNA:

see nucleic acidnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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DNA (deoxyribonucleic acid)

See GENETICS.

DNA

(biochemistry)

DNA

deoxyribonucleic acid; a nucleic acid that is the main constituent of the chromosomes of all organisms (except some viruses). The DNA molecule consists of two polynucleotide chains in the form of a double helix, containing phosphate and the sugar deoxyribose and linked by hydrogen bonds between the complementary bases adenine and thymine or cytosine and guanine. DNA is self-replicating, plays a central role in protein synthesis, and is responsible for the transmission of hereditary characteristics from parents to offspring

DNA

(1) See Windows DNA.

(2) (Digital Network Architecture) Introduced in 1978, it was Digital's umbrella term for its enterprise network architecture based on DECnet.
References in periodicals archive ?
DNA gyrase was isolated and purified according to a method described previously (10).
Topoisomerase IV lacks the ability to introduce negative supercoils into DNA, a function that is unique to DNA gyrase. (11)
DNA gyrase is essential for bacteria and plants but is not present in animals or humans.
Sharma et al., "Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model," Biochemistry, vol.
Reduced susceptibility to fluoroquinolones is usually associated with point mutations in the bacterial target genes encoding DNA gyrase and/ or DNA topoisomerase IV within the 'quinolone resistance determining region' (QRDR).27 In Salmonella, some of the more common point mutations found to be associated with resistance to quinolones occur in the gyrA gene resulting in substitutions at the Ser-83 position, often to Tyr, Phe or Ala, and Asp-87 substitutions to Asn, Gly or Tyr.
A recent example is the direct relation between the DNA gyrase functional mode of action and the applied mechanical stress (1).
leprae is GCA [right arrow] GTA in codon 91 of gyrA resulting in the substitution of valine for alanine (Ala91Val) in the [alpha]-subunit of the DNA gyrase.
Identification of pathogenic Leptospira species by conventional or real-time PCR and sequencing of the DNA gyrase subunit B encoding gene.
Specifically, they inhibit the activity of DNA gyrase and topoisomerase IV.
It functions by inhibiting DNA gyrase, a type II topoisomerase, which is an enzyme necessary to separate replicated DNA, thereby inhibiting cell division.
Quinolones have a bactericidal effect when these bind with two target enzymes, DNA gyrase and topoisomerase IV, which are essential for DNA replication within the cell.