Human xeroderma pigmentosum group D gene encodes a DNA helicase
While this is occurring, DNA helicase
, SSBs, and (depending on the precise reaction mixture) some other accessory factors come in and unwind the new nascent strand from the original template.
Dynamic effects of cofactors and DNA on the oligomeric state of human mitochondrial DNA helicase
The XPB and XPD DNA helicases
are components of the p53-mediated apoptosis pathway.
It involves a defect in a single gene (named WRN) that codes for a DNA helicase
, an enzyme that unwinds DNA in preparation for replication or repair.
uncoils DNA for a variety of replicative, transcriptional and repair processes, with failure resulting in increased genomic instability.
17 Cell, Bloom's syndrome results from mutations in the gene needed to produce an enzyme classified as a DNA helicase
In January 2005, Alnylam granted an exclusive license through its InterfeRx licensing program to GeneCare, a Japanese biotechnology firm, to discover, develop, and commercialize RNAi therapeutics directed against two DNA helicase
genes associated with cancer.