helicase

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helicase

[′hel·ə‚kās]
(biochemistry)
An enzyme that is capable of unwinding the deoxyribonucleic acid double helix at a replication fork.
References in periodicals archive ?
Human xeroderma pigmentosum group D gene encodes a DNA helicase.
While this is occurring, DNA helicase, SSBs, and (depending on the precise reaction mixture) some other accessory factors come in and unwind the new nascent strand from the original template.
Dynamic effects of cofactors and DNA on the oligomeric state of human mitochondrial DNA helicase.
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.
It involves a defect in a single gene (named WRN) that codes for a DNA helicase, an enzyme that unwinds DNA in preparation for replication or repair.
DNA helicase uncoils DNA for a variety of replicative, transcriptional and repair processes, with failure resulting in increased genomic instability.
17 Cell, Bloom's syndrome results from mutations in the gene needed to produce an enzyme classified as a DNA helicase.
In January 2005, Alnylam granted an exclusive license through its InterfeRx licensing program to GeneCare, a Japanese biotechnology firm, to discover, develop, and commercialize RNAi therapeutics directed against two DNA helicase genes associated with cancer.