DNA microarray


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DNA microarray

[¦dē¦en¦ā ′mī·krō·ə‚rā]
(cell and molecular biology)
A microscopic spot containing identical single-stranded polymeric molecules of deoxyribonucleotides (DNAs), usually oligonucleotides or complementary DNAs, attached to a solid support (such as a membrane, a polymer, or glass) used to simultaneously analyze the expression levels of the corresponding genes.
References in periodicals archive ?
DNA microarray analysis of differential gone expression in Borrelia burgdorferi, the Lyme disease spirochete, Proc Natl Acad Sci U S A.
This ongoing analysis is currently complemented with rarefaction of a 16S rRNA gene library derived from the same sample, demonstrating that it may indeed be possible to represent entire communities with reasonable effort on DNA microarrays.
- DNA Microarray (Type) Market Share (in %) by Company in Europe: 2019 & 2025
The field of DNA microarray has evolved from Ed Southern's key insight (Southern 1975) 25 years ago showing that labeled nucleic acid molecules could be used to interrogate nucleic acid molecules attached to a solid support.
The company has successfully developed high sensitivity DNA microarray 3D-Gene and a technology to efficiently extract microRNAs present in infinitesimal quantities in formalin-fixed, paraffin-embedded (FFPE) specimens and blood samples.
The assay involved DNase treatment of total RNA, reverse transcription of mRNA with oligo(dT) primer, triplex PCR amplification in the presence of biotin-dATP/biotin-dCTP, and hybridization of the resulting amplicons on a DNA microarray (see the Experimental Protocol in the Data Supplement that accompanies the online version of this Letter at http://www.clinchem.org/content/vol51/issuel2).
EG Microarray Killifish 750 is the world's first DNA microarray that has used killifish DNAs.
Mergen's ExpressChip DNA microarray system is a simple-to-use, cost-effective tool for high-throughput, high-sensitivity gene expression profiling.
research was carried out using DNA microarray technology to investigate strains isolated from chickens, food and humans.
Like all enabling technologies, DNA microarray analysis has manifold applications, and new ones will surely be developed.
DNA microarray technology has revolutionized biological research by enabling genome-scale explorations.