DNA vaccine

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DNA vaccine

[¦de¦en¦ā vak′sēn]
(immunology)
A type of noninfectious vaccine that directly injects deoxyribonucleic plasmids that express antigens of interest, resulting in foreign protein expression within the cells of the vaccine; however, the vaccine itself is unable to replicate.
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Although DNA vaccines can induce the body to produce antigen-specific humoral and cellular immunity, the efficiency of DNA vaccination is weaker in large animals and humans than in rodent models because naked DNA vaccines generally have weak stimulation on the immune system (Toussaint et al., 2005; Bins et al., 2013; Ghochikyan et al., 2013).
Dr Malone is an internationally recognised physician and scientist for his work in clinical trials in the areas of vaccines, gene therapy, biodefense and immunology, and specifically as one of the original inventors of DNA vaccination and multiple non-viral gene therapy technologies (RNA and DNA).
MDA5 can be exploited as efficacious genetic adjuvant for DNA vaccination against lethal H5N1 influenza virus infection in chickens.
Taken together, the described results of the studies previously performed by others and of those reported here support the use of E3-E26K-E1 as the most appropriate target antigens for a successful DNA vaccination strategy against encephalitic alphaviruses.
Levels of IgG antibodies in mice immunized with pVAX-GRA16 were increased with successive DNA vaccination and reached the highest level at 2 weeks after the third booster.
DNA vaccination of neonatal piglets in the face of maternal immunity induces humoral memory and protection against a virulent pseudorabies virus challenge.
DNA Vaccination: Here, DNA plasmids encoding genes required for antibodies production are transferred to an individual.
Rodrigues, "DNA sequences encoding [CD4.sup.+] and [CD8.sup.+] T-cell epitopes are important for efficient protective immunity induced by DNA vaccination with a Trypanosoma cruzi gene," Infection and Immunity, vol.
Scientists in a wide range of biomedical disciplines survey the status of new plasmids that have emerged in the development of non-viral vectors for gene and cell therapy and DNA vaccination. The topics include operator-repressor titration: stable plasmid maintenance without selectable marker genes, analytical tools in minicircle production, magnetofection of minicircle DNA vectors, the episomal expression of minicircles and conventional plasmids in mammalian embryos, and the influence of the extracellular matrix in the increased efficiency of minicircles versus plasmids under gene electrotransfer sub-optimal conditions.
showed that the serum levels of IL-10 in mice were increased following DNA vaccination with recombinant chimeric tachyzoite antigens.