(2) In particular, the introduction of SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors
over the past several years has produced an area of some clinical ambiguity, due to the lack of randomized controlled trials (RCTs) comparing their efficacy.
Overall, the median weight gain of 1.5 kg was observed in the insulin group, with no change of median weight in DPP-4 inhibitor
In the DPP-4 inhibitor
group, most exposures (49.7%) were to sitagliptin, 18.9% were to linagliptin, 10.4% were to saxagliptin, and the remaining exposures were to alogliptin, gemigliptin, teneligliptin, anagliptin, evogliptin, and trelagliptin (0.1%-4.7%).
There was no reduction in risk of death from a cardiovascular event for the drugs DPP-4 inhibitors
act in concert to stimulate insulin secretion, leading to improved glucose levels.
Overall, 16 studies investigated the effects of DPP-4 inhibitors
Firstly, DPP-4 inhibitors
increase NO release, but decrease the release of glucagon.
De Boer, "Early and late effects of the DPP-4 inhibitor
vildagliptin in a rat model of post-myocardial infarction heart failure," Cardiovascular Diabetology, vol.
The current T2DM in the Asia-Pacific (APAC) market contains novel products, including Jardiance - a SGLT-2 inhibitor; Victoza - a GLP-1 receptor agonist; and Galvus - a DPP-4 inhibitor
sitagliptin (JANUVIA) Merck's DPP-4 inhibitor
was administered to more than 14,000 patients.
 Sitagliptin, a DPP-4 inhibitor
, presents an alternative therapeutic strategy for patients with type 2 DM and, in general, shows significant improvements in glycemic control.
That's where DPP-4 inhibitor
sitagliptin comes to the rescue.