In the skin, Dsg1 is found throughout the epidermis and is expressed more intensely in the upper layer of the epidermis, whereas Dsg3 is found in the basal and parabasal cell layers.
If either Dsg 1 or Dsg3 function is disrupted because of an antibody directed against it, then Dsg1 or Dsg3 compensates for the impaired adhesive function of the other.
Orntoft, "Altered expression of CLC, DSG3
, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients," Cornea, vol.
Desmogleins are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.
The level of Dsg3 can be used as a read-out of pathogenic changes.
is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis.