Dvin


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Dvin

 

(Vostan Dvin), a major artisan and commercial city, center for transit of goods in Armenia from the fourth century to the 13th. Located 35 km south of Yerevan.

In the 330’s, the Armenian rulers, the Arsacids, built a fortress in Dvin and moved their residence there. After the fall of the Armenian Empire in 428. Dvin became the home of Armenia’s Persian rulers, and in 640. the center of the Arabemirate of Armenia. In 1236, Dvin was razed by the Mongols.

Systematic excavations of Dvin, including the fortress, the urban quarters, and the suburbs, have been under way since 1937. They offer much material on the culture of Armenia, of the fifth century to the I3th. Uncovered in the fortress were ruins of the palaces of the Armenian rulers, constructed after the earthquake of 893 (with ruins of palatial structures of the fourth century through the ninth under them), potters’ studios, and the apartments of functionaries, dating from the tenth century through the 13th. Also uncovered in the center of the city were remains of a cathedral which had been rebuilt in the seventh century from a basilica-like pagan temple of the third century, the palace of the Armenian catholicos (fifth century), a basilican church (sixth century), and the structure of a large caravansary (sixth century). Among the discoveries were artisan quarters, including workshops for pottery, glazed earthenware, glass-blowing, weaving, carpet-making, and jewelry, as well as residential homes, a system of water pipes, wine cellars, storehouses, and baths.

REFERENCES

Arutiunian, V. “Arkhitekturnye pamiatniki Dvina.” Izvestiia Akademii nauk Armianskoi SSR, 1947,no. 8.
Ghafadaryan, K. Dvin k‘aghak’e s nra peghumnere, book 1.Yerevan. 1952.

K. KAFADARIAN

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(1) However, the pathogenesis of dVIN is poorly understood and most of the evidence of dVIN as a precursor lesion to VSCC has been circumstantial until recently.
The recognition of dVIN can be a challenge, even for experienced gynecologic pathologists.
Notably, occasionally dVIN can present with basaloid features including nuclear atypia that extends beyond the basal layer, architectural disorganization, and homogeneous populations of basaloid undifferentiated keratinocytes.
Nevertheless, if dVIN is highly suspected clinically, the case should be reviewed by an experienced gynecologic pathologist.
Use of biomarkers for recognizing dVIN, however, has some limitations and is considered a work in progress.
Ki-67 can be another helpful marker to distinguish dVIN from reactive changes, normal epithelium, and uVIN.
Dvin, slaughtered 12,000 of its inhabitants and carried 35,000 into slavery.
the Historian, Dvin was captured in 640 during the reign of Constans II and Catholicos Ezra.
fact that Dvin was a battleground between Arabs and Byzantine forces for the next two centuries, in the 9th century, it was still a
Upregulation was observed in dVIN versus LS (P = .01, Fisher exact test).
Significant differences for hTERT/ survivin and p53 overexpression were calculated for dVIN (0% versus 45%, P = .003, Fisher exact test), consistent with a lack of a correlation in this type of preinvasive and intraepithelial lesions.
This observation is supported by van der Avoort et al (27) who compared DNA ploidy measurements and high p53 expression in neoplasias of the vulva and suggested that dVIN has a higher malignant potential than LS and thus is a more likely precursor of squamous cell carcinoma.