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The deterioration of existing defense mechanisms, leading to an exacerbation of pathologic behavior.



disturbance of the activity of an organ, a system of organs, or the entire organism, as a result of exhaustion or disruption of its adaptive mechanisms.

Harmful influences that cause significant changes in the organism disturb the constant equilibrium between the organism and the external environment. After some time, the organism adapts itself to the new conditions of existence (for example, the heart muscle hypertrophies when there are heart defects) and equilibrium is restored—that is, compensation occurs. When there is compensation, the organ (or system) works under an increased load, as a result of which it succumbs more readily to harmful influences.

References in periodicals archive ?
Among these categories patients were divided as Non cirrhotic and Cirrhotic furthermore,cirrhotic involves Compensated CLD and Decompensated CLD.
Acute Decompensated Heart Failure is a severe episode of acute respiratory distress in which a heart failure patient experiences a sudden or gradual onset of the signs of heart failure that requires either initiation or escalation of treatment to relieve symptoms and prevent death.
Group A comprising of patients with decompensated cirrhosis in Child Pugh class C and group B of patients with compensated cirrhosis in Child Pugh class A.
Applying this three-measure assessment to patients hospitalized with acute decompensated heart failure "may guide care-transition planning and promote efficient allocation of limited resources," said Dr.
M2 EQUITYBITES-November 3, 2015-Bristol-Myers Squibb announces agreement to purchase Cardioxyl Pharmaceuticals, including novel nitroxyl (HNO) donor in Phase 2 development for acute decompensated heart failure
received approval in the Philippines for LIVAMIN Oral Granules indicated for the improvement of hypoalbuminemia(1) in patients with decompensated hepatic cirrhosis presenting with hypoalbuminemia despite adequate dietary intake.
The primary efficacy endpoint of the trial is a time-to-first event analysis of heart failure-related Major Adverse Cardiac Events (HFMACE), defined as a composite of cardiac related death or resuscitated cardiac death, or non-fatal decompensated heart failure events.
Use of isolated extracorporeal ultrafiltration to treat decompensated heart failure: technical difficulties and clinical evolution
Once the structural damage comprises ~80% of the organ, the liver cirrhosis progresses to the decompensated stage when the liver is no longer able to function properly.
This systematic review and meta-analysis examines the association between air pollution and acute decompensated heart failure, including hospitalisation and heart failure mortality.
We describe the successful management of decompensated RV failure with a combination of selective pulmonary vasodilators and levosimendan in a critical patient with non-operable CTEPH.
A very simple five-step approach can often be enough to alleviate symptoms of a decompensated phoria.