Dehydrogenases


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Dehydrogenases

 

enzymes that catalyze the removal of hydrogen from organic compounds. The coenzymes of dehydrogenases are usually dinucleotides: nicotinamide adenine dinucleotide (NAD), nicotinamide adenine dinucleotide phosphate (NADP), or flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), which accept hydrogen from the oxidizable substance. Dehydrogenases bring about the first stage of biological oxidation and play a large part in the Krebs cycle, glycolysis, and the pentose phosphate cycle. In the organism the NADP, reduced through the action of certain dehydrogenases, is used to synthesize fatty acids. Some dehydrogenases, unconnected with coenzymes, catalyze the direct oxidation of substances by oxygen. Many dehydrogenases contain metals (zinc or manganese) that are part of their active centers.

G. Z. SOLOV’EVA

References in periodicals archive ?
Accordingly, certain cancers are associated with genetic aberrations in TCA cycle enzymes, such as isocitrate dehydrogenase 1 (IDH1), isocitrate dehydrogenase 2 (IDH2), succinate dehydrogenase (SDH), fumarate hydratase (FH), and L-2-hydroxyglutarate dehydrogenase.
The analyzed proteins include the complex I or NADH dehydrogenase subunits, the A and B subunits of complex II or succinate dehydrogenase, and various subunits of complex III or cytochrome bcl.
Cook, "Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase," Microbiology, vol.
Activities of mitochondrial dehydrogenases were determined spectrophotometrically as NADH oxidoreductases (NDH, monitored at 340 nm, [[epsilon].sub.340] = 6.22 [mM.sup.-1]x [cm.sup.-1]) or Co[Q.sub.1] oxidoreductases (SDH and mGPDH, monitored at 275 nm, [[epsilon].sub.275] = 13.6 [mM.sup.-1] x [cm.sup.- 1]).
Recent advances in 17betahydroxysteroid dehydrogenases. J Steroid Biochem Mol Biol 2009 Mar; 114(1-2): 72-77.
Of these patients 59% were diagnosed as IDA.3 Glucose-6phosphate dehydrogenase (G6PD) catalyzes the rate-determining step in the pentose phosphate pathway and produces NADPH to fuel glutathione recycling.
The objectives of this study were (1) to quantify the activities of five soil enzymes (invertase, urease, phosphatase, catalase, and dehydrogenase) and selected soil physicochemical properties across an entire county (Changwu) on the Loess Plateau; (2) to investigate the spatial variability of soil enzyme activities in a representative area in the Hilly-Gully Region of Loess Plateau; and (3) to explore the relationships between soil enzyme activities and physicochemical properties using an integrated soil enzyme activity index (TEI) and to compare it with the geometric mean of enzyme activities (GME).
In the bacterium Clostridium kluyveri an NAD(P)H-dependent flavoenzyme dihydrolipoyl dehydrogenase (synonymously called dihydrolipoamide dehydrogenase) reduces Fe(III) complexes of citrate, ATP, and ADP [2].
Glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49, [beta]-D-glucose-6-phosphate; NADP oxidoreductase) is the initial and the key regulatory enzyme in the pentose phosphate pathway [1-4].
(iii) related enzymes may exhibit SI in some conditions, as is the case glutamate dehydrogenase [4].