Deoxycorticosterone


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Related to Deoxycorticosterone: Desoxycorticosterone

deoxycorticosterone

[dē¦äk·sē‚kȯrd·ə′kä·stə‚rōn]
(biochemistry)
C21H30O3 A steroid hormone secreted in small amounts by the adrenal cortex.

Deoxycorticosterone

 

(also cortexone), an intermediate product in the biosynthesis of hormones of the adrenal cortex. Formed primarily from progesterone, it is a mineralocorticoid, that is, an active regulator of mineral metabolism, and in this connection the most stable preparation of deoxycorticosterone is deoxycorticosterone acetate, which is used in medicine.

References in periodicals archive ?
The results showed that adrenodoxin was highly autooxidizable in the reconstituted system, which confirmed Kimura's report, (44) and only small fraction of enzymatically reduced adrenodoxin was utilized for the deoxycorticosterone 11[beta]-hydroxylation.
Though aldosterone levels are decreased but salt retaining properties of 11 deoxycorticosterone result in hypertension.
Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats.
Female neonates with ambiguous genitalia and male with precocious puberty are in the highest risk category to develop HTN because of the high secretion of deoxycorticosterone (DOC).
Reduction by coenzyme Q10 of hypertension induced by deoxycorticosterone and saline in rats.
Steroid concentrations in the medium and cell lysate were measured using liquid chromatography/mass spectrometry for 12 steroids [pregnenolone (PREG), 17[alpha]-hydroxypregnenolone (HPREG), dehy-droepiandrosterone (DHEA), progesterone (PROG), 17[alpha]-hydroxyprogesterone (HPROG), androstenedione (DIONE), testosterone (T), deoxycorticosterone (DCORTICO), corticos-terone (CORTICO), ALDO, 11-deoxycortisol (DCORT), and CORT] and using enzyme-linked immunosorbent assay for two additional steroids [estrone ([E.
7,66,67) An aldosterone precursor, deoxycorticosterone is converted by the same enzymes to a neurosteroid with similar effects called 3[alpha], 5[alpha]-tetrahydro-deoxycortone (THDOC).
Yang, "Relative contributions of mitochondria and NADPH oxidase to deoxycorticosterone acetate-salt hypertension in mice," Kidney International, vol.