Dephosphorylation


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Dephosphorylation

 

the splitting-off of a phosphoric acid group from a molecule of a compound containing phosphorus. Some unstable organic phosphorus compounds can undergo spontaneous dephosphorylation, but in living organisms dephosphorylation proceeds primarily with the participation of enzymes. Dephosphorylation brought about by kinases (creatine kinase, glucokinase, and so on) leads to the transfer of the phosphoric acid group to other compounds. Dephosphorylation that is catalyzed by phosphorylases (phosphoamidases) results in the formation of free phosphoric acid. The differentiation among the various types of fermentative dephosphorylation is to some extent arbitrary.

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Veum, (1995) An in vitro procedure for studying enzymic dephosphorylation of phytate in maize-soyabean feeds for turkey poults.
From an enzymology perspective, sensor kinases are interesting because many of them participate in three distinct but related reactions such as autophosphorylation, phosphotransfer and dephosphorylation. Sensor kinases are modular proteins with distinct structural domains playing different functional roles.
Lnc-DC Lnc-DC promotes phosphorylation and [35] [35] activation of STAT3, a transcription essential for DC differentiation, by blocking its dephosphorylation by SHP1.
RASSF1A may keep MST1/2 at its phosphorylated state and prevent dephosphorylation by binding to MST1/2 [12].
Indirectly, ceramide activates protein phosphatase 2A (PP2A), resulting in increases of the proapoptotic Bcl-2 family proteins by dephosphorylation of Bax (activation) and Bcl-2 (inactivation) [58].
In this model, the two phosphatases are grouped into a single enzyme catalyzing the dephosphorylation of AKT.
[124] demonstrated in Ruminococcus flavefaciens, a cellulolytic bacterium, that the phosphorylation and dephosphorylation dynamics are important for carbon source recognition and regulation of carbon metabolism.
Paul, "Myosin phosphorylation/ dephosphorylation and regulation of airway smooth muscle contractility," American Journal of Physiology-Lung Cellular and Molecular Physiology, vol.
However, when combined with cisplatin, melatonin synergistically cooperate with the chemo drug to diminish the viability in this cell line, effect accompanied by an increase in the cleavage of PARP and caspase-3, an inhibition of ERK phosphorylation along with dephosphorylation of p90RSK and HSP27.
Fourth, phosphatase and protease inhibitor cocktails were used in the PSD phosphorylation reactions to disrupt dephosphorylation and proteolysis reactions.
The relaxation and contraction of smooth muscle cells is controlled by the phosphorylation and dephosphorylation of the myosin light chain.
This has been observed from the arrest of cell proliferation when Ki-67 is blocked either by microinjection of blocking antibodies or by inhibition of dephosphorylation. The Ki-67 expression is estimated as the percentage of the tumour cells positively stained by the antibody with nuclear staining being most common criterion of positivity.