depurination


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depurination

[dē‚pyu̇r·ə′nā·shən]
(biochemistry)
Detachment of guanine from sugar in a deoxyribonucleic acid molecule.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Further research is needed to confirm whether other types of DNA damage, such as base oxidation, depurination of depyrimidation, are caused by LF-EMR.
It can act by causing acid catalyzed depurination, randomly removing A and G bases from DNA and leaving "gaps" or chain breaks which can't be amplified across.
Others discuss DNA self-catalyzed depurination, B12-dependent photoreceptors, engineering and in vivo applications of riboswitches, cyclic GMP-AMP as an endogenous second messenger, antibiotics, surface-active and surfactant proteins, functionally diverse lipid-binding compartments, the evolution of membrane coating complexes, endoplasmic reticulum-plasma membrane contact sites, mitochondrial biogenesis, oxidative stress, mammalian peroxiredoxins, redox-based regulation of bacterial behavior, heme uptake and bacterial cell membranes, biological probes built from fluoresceins and rhodamines, microbial rhodopsins, and cellular electron cryotomography.
Purine and pyrimidine abasic sites (AP sites) are among the most frequent lesions in cellular nucleic acids formed via spontaneous base loss, mainly depurination, and as intermediates in the enzymatic base excision repair process of various other base lesions [299].
Exposure of DNA to RNS can promote deamination of DNA bases and conversion of guanine into xanthine, oxanine, and 8-nitroguanine, which is rapidly lost from DNA by spontaneous depurination. The major end products of HClO include 5-chlorocytosine and 5-chlorouracil.
The depurination rate of single-stranded DNA is 4 times higher than that of double-stranded DNA (33).
Pischetsrieder, "DNA-glycation leads to depurination by the loss of N2-carboxyethylguanine in vitro," Cellular and Molecular Biology, vol.
This depurination inactivates the ribosome, thereby blocking its further participation in protein synthesis.
2%) of DNA cleavage was observed, ruling out the possibility of DNA cleavage via OH-based depurination pathway and also a possible oxidative cleavage [48,49].
Evidence that a burst of DNA depurination in SENCAR mouse skin induces error-prone repair and forms mutations in the H-ras gene.
Heating in the presence of a strong acid causes depurination (the release of the purine bases) and hydrolysis of the RNA strands to give free pyrimidine nucleotides, ribose, and phosphate.