Once again, the alternative adhesion junction complexes that have been implicated in later stages of cancer appeared to be present and functioning normally in almost all of these samples, further supporting the idea that desmosome
loss due to Perp inactivation can be an early, defining event in cancer progression.
Junctional complexes, desmosomes
and interdigitations are found between adjacent cells.
As the sequence of peptide contained in Cellcon is derived from desmoglein-1, the higher amount of this sequence in a cell simulates desmosome
Blisters occur in the epidermis and the mucous membranes, where the IgG autoantibodies target two structural proteins of the desmosomes
identified as desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3).A new pemphigus antigen, desmoglein 4, has recently been discovered and implicated in the pathogenesis of PV.
(3) In addition to storing antigens as cell surface immune complexes for long periods of time, follicular dendritic cells are a nonmigrating population likely derived from the stroma that assist in the architectural support of the lymphoid follicles via cellto-cell attachments and desmosomes
Electron microscopy shows the basaloid component to have desmosomes
, rare tonofilaments and loose stellate granules or replicated basal lamina within the cystic spaces.
In sheets or clusters, adjacent cells are connected by desmosomes
anchored by cytoskeletal elements (Kolega, 1986; Abraham et al., 2001).
[10,11] Two factors that support this belief are that the kidney is a very vascular organ and that desmosomes
are reduced in renal carcinoma cells.
(13) Breakthroughs in this setting informed the field that dysfunctional desmosomes
may be the root of the disease and led to the discovery of many desmosomal genes implicated in AC (Table 2).
It consisted of a tight junction, a gap junction, intermediate junction, desmosomes
and septate junction (Fig.
Prominent microvilli, desmosomes
and tonofilaments if seen are highly suggestive of ATE (14).
The dividing cells are joined to their neighbors by desmosomes
and retain secretory vacuoles in their cytoplasm.