(arrow) is the target of pemphigus vulgaris.
The team from the Faculty of Life Sciences studied how cells in the skin and heart are bound together through structures called desmosomes
[Figure 6] were visible between Tps of different TCs, forming an intricate three-dimensional network in tunica adventitia.
In the stratum granulosum, cells have tight junctions mediated by desmosomes
(cell structures remaining attached to neighboring cells) that act as a diffusion barrier in the rumen wall.
Since the desmosomes
are the primary attachment mechanism between keratinocytes, this disease results in acantholysis in epidermis .
occupied a central position in the interspace with taut, thin cytoplasmic strands connecting them to the opposing cells.
The proteins associated with desmosomes
namely desmoglein 1 and 3 are affected in this condition wherein auto-antibodies are directed against these proteins.
Desmoglein 3 is an extracellular adhesion protein of the cadherin superfamily that is found in desmosomes
, which are cell-cell junctions found in epithelial, myocardial, and other cell types.
Washington, Apr 20 ( ANI ): The protein Perp, associated with desmosomes
(the glue that sticks cells together), is involved in suppressing breast cancer and offers a potential new target for future treatment, a new study has revealed.
Trophoblast cells of sheep are united laterally by desmosomes
and are low cuboidal until d 12, after which time they become columnar and more secretory by d 14.
Ultrastructural studies show that E-cadherin on the cytoplasmic membrane of the keratinocytes is shifted to desmosomes
under physiological conditions and therein expresses an adhesion function in association with other desmosomal cadherins.
Desmogleins are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes
between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.