Desmosomes


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Related to Desmosomes: Gap junctions

Desmosomes

 

(from Greek desmos, “ligament,” “band” and soma, “body”), surface structures of animal cells, which make it possible for them to be connected to one another. Previously desmosomes were thought to be intercellular bridges. However, electron-microscope research has shown that each desmosome consists of two “halves” (that belong to neighboring cells), divided by a slit-like space (100-200 angstroms). The outer part of the desmosome, which is turned toward the slit-like space, apparently consists of a thickening of the plasma membrane. Next to it lies a wider part formed by a network of fibrillae. Despite the morphological isolation of the desmosome “halves,” cells where they are located are more firmly connected to one another.

References in periodicals archive ?
The team from the Faculty of Life Sciences studied how cells in the skin and heart are bound together through structures called desmosomes.
The desmosomes [Figure 6] were visible between Tps of different TCs, forming an intricate three-dimensional network in tunica adventitia.
In the stratum granulosum, cells have tight junctions mediated by desmosomes (cell structures remaining attached to neighboring cells) that act as a diffusion barrier in the rumen wall.
Since the desmosomes are the primary attachment mechanism between keratinocytes, this disease results in acantholysis in epidermis [1].
The desmosomes occupied a central position in the interspace with taut, thin cytoplasmic strands connecting them to the opposing cells.
The proteins associated with desmosomes namely desmoglein 1 and 3 are affected in this condition wherein auto-antibodies are directed against these proteins.
Desmoglein 3 is an extracellular adhesion protein of the cadherin superfamily that is found in desmosomes, which are cell-cell junctions found in epithelial, myocardial, and other cell types.
Washington, Apr 20 ( ANI ): The protein Perp, associated with desmosomes (the glue that sticks cells together), is involved in suppressing breast cancer and offers a potential new target for future treatment, a new study has revealed.
Trophoblast cells of sheep are united laterally by desmosomes and are low cuboidal until d 12, after which time they become columnar and more secretory by d 14.
Ultrastructural studies show that E-cadherin on the cytoplasmic membrane of the keratinocytes is shifted to desmosomes under physiological conditions and therein expresses an adhesion function in association with other desmosomal cadherins.
Desmogleins are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.