Desmosomes


Also found in: Dictionary, Medical.
Related to Desmosomes: Gap junctions
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Desmosomes

 

(from Greek desmos, “ligament,” “band” and soma, “body”), surface structures of animal cells, which make it possible for them to be connected to one another. Previously desmosomes were thought to be intercellular bridges. However, electron-microscope research has shown that each desmosome consists of two “halves” (that belong to neighboring cells), divided by a slit-like space (100-200 angstroms). The outer part of the desmosome, which is turned toward the slit-like space, apparently consists of a thickening of the plasma membrane. Next to it lies a wider part formed by a network of fibrillae. Despite the morphological isolation of the desmosome “halves,” cells where they are located are more firmly connected to one another.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Once again, the alternative adhesion junction complexes that have been implicated in later stages of cancer appeared to be present and functioning normally in almost all of these samples, further supporting the idea that desmosome loss due to Perp inactivation can be an early, defining event in cancer progression.
As the sequence of peptide contained in Cellcon is derived from desmoglein-1, the higher amount of this sequence in a cell simulates desmosome degradation.
Blisters occur in the epidermis and the mucous membranes, where the IgG autoantibodies target two structural proteins of the desmosomes identified as desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3).A new pemphigus antigen, desmoglein 4, has recently been discovered and implicated in the pathogenesis of PV.
(3) In addition to storing antigens as cell surface immune complexes for long periods of time, follicular dendritic cells are a nonmigrating population likely derived from the stroma that assist in the architectural support of the lymphoid follicles via cellto-cell attachments and desmosomes. (4,5)
Electron microscopy shows the basaloid component to have desmosomes, rare tonofilaments and loose stellate granules or replicated basal lamina within the cystic spaces.
In sheets or clusters, adjacent cells are connected by desmosomes anchored by cytoskeletal elements (Kolega, 1986; Abraham et al., 2001).
[10,11] Two factors that support this belief are that the kidney is a very vascular organ and that desmosomes are reduced in renal carcinoma cells.
(13) Breakthroughs in this setting informed the field that dysfunctional desmosomes may be the root of the disease and led to the discovery of many desmosomal genes implicated in AC (Table 2).
Prominent microvilli, desmosomes and tonofilaments if seen are highly suggestive of ATE (14).
The dividing cells are joined to their neighbors by desmosomes and retain secretory vacuoles in their cytoplasm.