Dextran

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dextran

[′dek ‚stran]
(biochemistry)
Any of the several polysaccharides, (C5H10O5)n , that yield glucose units on hydrolysis.

Dextran

 

(C6H10O5)n, a polysaccharide of bacterial origin, a polymer of glucose. The molecular weight can be as high as 10,000,000. In the linear part of the dextran molecule the glucose residues are joined by bonds between the first and sixth carbon atoms; branching is due to bonds between the first and fourth, first and third, and first and second atoms. Dextran is obtained by growing microorganisms of the genus Leuconostoc in an artificial culture medium. Dextran, in the form of a partially hydrolyzed solution with not less than 90 percent 1.6 linkages and a molecular weight of about 60,000 is used clinically as a blood plasma substitute. The preparation provides for a normal osmotic pressure corresponding to that of blood. Modified dextran, so-called Sephadex, is used in chromatography.

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A complete retrospective review of all dialysis run sheets and nursing progress notes of patients who received Dexferrum was conducted.
The use of Dexferrum diluted in an IV solution is not in the product labeling).
The first, a moderate reaction, was judged to be related to Dexferrum, while the second, a cardiac arrest, was judged not to be related.
The adverse event associated with Dexferrum therapy occurred in an 84-year-old, white, male with a history of coronary artery disease.