Dextran

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Related to Dexferrum: Imferon

dextran

[′dek ‚stran]
(biochemistry)
Any of the several polysaccharides, (C5H10O5)n , that yield glucose units on hydrolysis.

Dextran

 

(C6H10O5)n, a polysaccharide of bacterial origin, a polymer of glucose. The molecular weight can be as high as 10,000,000. In the linear part of the dextran molecule the glucose residues are joined by bonds between the first and sixth carbon atoms; branching is due to bonds between the first and fourth, first and third, and first and second atoms. Dextran is obtained by growing microorganisms of the genus Leuconostoc in an artificial culture medium. Dextran, in the form of a partially hydrolyzed solution with not less than 90 percent 1.6 linkages and a molecular weight of about 60,000 is used clinically as a blood plasma substitute. The preparation provides for a normal osmotic pressure corresponding to that of blood. Modified dextran, so-called Sephadex, is used in chromatography.

References in periodicals archive ?
The total ADE reporting rates for Dexferrum, INFeD, sodium ferric gluconate, and iron sucrose were 129, 40.2, 19.4, and 19.8 reports per million/100 mg equivalents, respectively, whereas the absolute rates of life-threatening events were 11.3, 3.3, 0.6, and 0.9 per million.
[24] Dexferrum (Prescribing Information), American Regent Laboratories, Shirley, NY, USA, 2010.
Product name ASP per gram Iron dextran (Infed) $240.0 Iron dextran (Dexferrum) $240.0 Iron sucrose (Venofer) $285.0 Sodium ferric gluconate (Ferrlecit) $265.2 Ferumoxytol (Feraheme) $638.0
We calculated the incidence of adverse events as a percentage of the total number of patients treated with Dexferrum. Due to the small number of adverse events, we did not analyze potential predictors of such events.
A complete retrospective review of all dialysis run sheets and nursing progress notes of patients who received Dexferrum was conducted.
(The use of Dexferrum diluted in an IV solution is not in the product labeling).